Generalized potential of adult neural stem cells

被引：797

作者：

Clarke, DL

Johansson, CB

Wilbertz, J

Veress, B

Nilsson, E

Karlström, H

Lendahl, U

Frisén, J

机构：

[1] Med Nobel Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden

[2] Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden

来源：

SCIENCE | 2000年 / 288卷 / 5471期

关键词：

D O I：

10.1126/science.288.5471.1660

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The differentiation potential of stem ce(Ls in tissues of the adult has been thought to be Limited to cell lineages present in the organ from which they were derived, but there is evidence that some stem cells may have a broader differentiation repertoire. We show here that neural stem cells from the adult mouse brain can contribute to the formation of chimeric chick and mouse embryos and give rise to cells of all germ layers. This demonstrates that an adult neural stem cell has a very broad developmental capacity and may potentially be used to generate a variety of cell types for transplantation in different diseases.

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页码：1660 / 1663

页数：4

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