Diabetic cardiomyopathy revisited

被引：1374

作者：

Boudina, Sihem ^{[1
]}

Abel, E. Dale ^{[1
]}

机构：

[1] Univ Utah, Sch Med, Div Endocrinol Metab & Diabet, Program Human Mol Biol & Genet, Salt Lake City, UT 84112 USA

来源：

CIRCULATION | 2007年 / 115卷 / 25期

关键词：

diabetes mellitus; fatty acids; heart failure; metabolism; obesity; CONGESTIVE-HEART-FAILURE; ACTIVATED RECEPTOR-ALPHA; CORONARY-ARTERY-DISEASE; FATTY-ACID OXIDATION; REDUCED CARDIAC EFFICIENCY; LEFT-VENTRICULAR STRUCTURE; OBESE ZUCKER RATS; BB WOR RAT; INSULIN-RESISTANCE; CONTRACTILE DYSFUNCTION;

D O I：

10.1161/CIRCULATIONAHA.106.679597

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying pathogenesis is partially understood. Several factors may contribute to the development of cardiac dysfunction in the absence of coronary artery disease in diabetes mellitus. This review discusses the latest findings in diabetic humans and in animal models and reviews emerging new mechanisms that may be involved in the development and progression of cardiac dysfunction in diabetes.

引用

页码：3213 / 3223

页数：11

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