Role of changes in cardiac metabolism in development of diabetic cardiomyopathy

被引:352
作者
An, Ding [1 ]
Rodrigues, Brian [1 ]
机构
[1] Univ British Columbia, Div Pharmacol & Toxicol, Fac Pharmaceut Sci, Vancouver, BC V6T 1Z3, Canada
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2006年 / 291卷 / 04期
关键词
heart disease; diabetes; insulin resistance; lipoprotein lipase; fatty acid transporters; PPARs; lipotoxicity; mitochondria dysfunction;
D O I
10.1152/ajpheart.00278.2006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In patients with diabetes, an increased risk of symptomatic heart failure usually develops in the presence of hypertension or ischemic heart disease. However, a predisposition to heart failure might also reflect the effects of underlying abnormalities in diastolic function that can occur in asymptomatic patients with diabetes alone (termed diabetic cardiomyopathy). Evidence of cardiomyopathy has also been demonstrated in animal models of both Type 1 (streptozotocin-induced diabetes) and Type 2 diabetes ( Zucker diabetic fatty rats and ob/ob or db/db mice). During insulin resistance or diabetes, the heart rapidly modifies its energy metabolism, resulting in augmented fatty acid and decreased glucose consumption. Accumulating evidence suggests that this alteration of cardiac metabolism plays an important role in the development of cardiomyopathy. Hence, a better understanding of this dysregulation in cardiac substrate utilization during insulin resistance and diabetes could provide information as to potential targets for the treatment of cardiomyopathy. This review is focused on evaluating the acute and chronic regulation and dysregulation of cardiac metabolism in normal and insulin-resistant/diabetic hearts and how these changes could contribute toward the development of cardiomyopathy.
引用
收藏
页码:H1489 / H1506
页数:18
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