Human brain endothelial cells supply support for monocyte immunoregulatory functions

被引：7

作者：

Séguin, R ^{[1
]}

Moditi, Z ^{[1
]}

Rotondo, R ^{[1
]}

Biernacki, K ^{[1
]}

Wosik, K ^{[1
]}

Prat, A ^{[1
]}

Antel, JP ^{[1
]}

机构：

[1] Montreal Neurol Inst, Neuroimmunol Unit, Montreal, PQ H3B 2A4, Canada

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 135卷 / 1-2期

关键词：

human brain-derived endothelial cells; transendothelial migration; APC;

D O I：

10.1016/S0165-5728(02)00431-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Blood-derived monocytic cells comprise a significant component of most inflammatory responses that occur in the CNS. We utilized human brain-derived endothelial cells (HBECs) coated membranes in Boyden chambers to assess immune function related properties of human blood-derived monocytes following interaction with HBECs. Monocytes in contact with HBECs maintained functional antigen-presenting capacity and chemokine/cytokine production in contrast to monocytes that migrated through the HBEC barrier. These results indicate that HBECs, although themselves incapable of serving as competent antigen-presenting cells during the course of inflammatory CNS disorders, supply support needed for infiltrating perivascular monocytes to maintain their functions. Monocyte migration across HBECs was inhibited by interferon-beta. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：96 / 106

页数：11

共 32 条

[11]

la Sala A, 2000, J LEUKOCYTE BIOL, V68, P104

[12]

Lombard MA, 1998, CANCER RES, V58, P4001

[13]

McManus CM, 2000, GLIA, V29, P273, DOI 10.1002/(SICI)1098-1136(20000201)29:3<273::AID-GLIA8>3.3.CO

[14]

2-0

[15] Neurotrophins inhibit major histocompatibility class II inducibility of microglia: Involvement of the p75 neurotrophin receptor [J].

Neumann, H ;

Misgeld, T ;

Matsumuro, K ;

Wekerle, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (10) :5779-5784

[16] Multiple sclerosis:: Pro- and anti-inflammatory cytokines and metalloproteinases are affected differentially by treatment with IFN-β [J].

Özenci, V ;

Kouwenhoven, M ;

Teleshova, N ;

Pashenkov, M ;

Fredrikson, S ;

Link, H .

JOURNAL OF NEUROIMMUNOLOGY, 2000, 108 (1-2) :236-243

[17] Kinin B1 receptor expression and function on human brain endothelial cells [J].

Prat, A ;

Biernacki, K ;

Pouly, S ;

Nalbantoglu, J ;

Couture, R ;

Antel, JP .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2000, 59 (10) :896-906

[18]

Prat A, 1999, ANN NEUROL, V46, P253, DOI 10.1002/1531-8249(199908)46:2<253::AID-ANA16>3.0.CO

[19]

2-C

[20] B7 expression and antigen presentation by human brain endothelial cells: Requirement for proinflammatory cytokines [J].

Prat, A ;

Biernacki, K ;

Becher, B ;

Antel, JP .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2000, 59 (02) :129-136

← 1 2 3 4 →