Human brain endothelial cells supply support for monocyte immunoregulatory functions

被引：7

作者：

Séguin, R ^{[1
]}

Moditi, Z ^{[1
]}

Rotondo, R ^{[1
]}

Biernacki, K ^{[1
]}

Wosik, K ^{[1
]}

Prat, A ^{[1
]}

Antel, JP ^{[1
]}

机构：

[1] Montreal Neurol Inst, Neuroimmunol Unit, Montreal, PQ H3B 2A4, Canada

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 135卷 / 1-2期

关键词：

human brain-derived endothelial cells; transendothelial migration; APC;

D O I：

10.1016/S0165-5728(02)00431-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Blood-derived monocytic cells comprise a significant component of most inflammatory responses that occur in the CNS. We utilized human brain-derived endothelial cells (HBECs) coated membranes in Boyden chambers to assess immune function related properties of human blood-derived monocytes following interaction with HBECs. Monocytes in contact with HBECs maintained functional antigen-presenting capacity and chemokine/cytokine production in contrast to monocytes that migrated through the HBEC barrier. These results indicate that HBECs, although themselves incapable of serving as competent antigen-presenting cells during the course of inflammatory CNS disorders, supply support needed for infiltrating perivascular monocytes to maintain their functions. Monocyte migration across HBECs was inhibited by interferon-beta. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：96 / 106

页数：11

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