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Sox-2 is expressed by glial and progenitor cells and Pax-6 is expressed by neuroblasts in the human subventricular zone

被引：29
作者：
Baer, Kristin
Eriksson, Peter S.
Faull, Richard L. M.
Rees, Mark I.
Curtis, Maurice A.
机构：
[1] Univ Wales Swansea, Sch Med, Swansea SA2 8PP, W Glam, Wales
[2] Univ Gothenburg, Inst Neurosci & Physiol, Ctr Brain Repair & Rehabil, S-40530 Gothenburg, Sweden
[3] Univ Auckland, Dept Anat & Radiol, Auckland 1, New Zealand
来源：
EXPERIMENTAL NEUROLOGY | 2007年 / 204卷 / 02期
关键词：
human brain; neurogenesis; transcription factor; progenitor cell; subventricular zone; bromodeoxyuridine;
D O I：
10.1016/j.expneurol.2006.12.008
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Transcription factors (TFs) are responsible for the specification and fate determination of cells as they develop from progenitor cells into specific types of cells in the brain. Sox-2 and Pax-6 are TFs with key functional roles in the developing brain, although less is known about TFs in the rudimentary germinal zones in the adult human brain. In this study we have investigated the distribution and characterization of Sox-2 and Pax-6 in the human subventricular zone (SVZ). Sox-2 immunoreactivity showed a nuclear labeling pattern and colocalised on GEAP immunoreactive cells as well as on bromodeoxyuridine (BrdU)-positive cells, whereas Pax-6 immumoreactivity was detectable in the nucleus and the cytoplasm of SVZ cells and colocalised with PSA-NCAM-positive progenitor cells. Thus, our data surprisingly reveal that these TFs are differentially expressed in the adult human SVZ where Sox-2 and Pax-6 specify a glial and neuronal fate, respectively. (c) 2006 Elsevier Inc. All rights reserved.
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页码：828 / 831
页数：4
相关论文
共 17 条
[1]   Neuronal replacement from endogenous precursors in the adult brain after stroke [J].
Arvidsson, A ;
Collin, T ;
Kirik, D ;
Kokaia, Z ;
Lindvall, O .
NATURE MEDICINE, 2002, 8 (09) :963-970
[2]   Vertebrate neurogenesis is counteracted by Sox1-3 activity [J].
Bylund, M ;
Andersson, E ;
Novitch, BG ;
Muhr, J .
NATURE NEUROSCIENCE, 2003, 6 (11) :1162-1168
[3]   Properties of a fetal multipotent neural stem cell (NEP cell) [J].
Cai, JL ;
Wu, YY ;
Mirua, T ;
Pierce, JL ;
Lucero, MT ;
Albertine, KH ;
Spangrude, GJ ;
Rao, MS .
DEVELOPMENTAL BIOLOGY, 2002, 251 (02) :221-240
[4]   The distribution of progenitor cells in the subependymal layer of the lateral ventricle in the normal and Huntington's disease human brain [J].
Curtis, MA ;
Penney, EB ;
Pearson, J ;
Dragunow, M ;
Connor, B ;
Faull, RLM .
NEUROSCIENCE, 2005, 132 (03) :777-788
[5]   Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain [J].
Curtis, MA ;
Penney, EB ;
Pearson, AG ;
van Roon-Mom, WMC ;
Butterworth, NJ ;
Dragunow, M ;
Connor, B ;
Faull, RLM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (15) :9023-9027
[6]   Neurogenesis in the adult human hippocampus [J].
Eriksson, PS ;
Perfilieva, E ;
Björk-Eriksson, T ;
Alborn, AM ;
Nordborg, C ;
Peterson, DA ;
Gage, FH .
NATURE MEDICINE, 1998, 4 (11) :1313-1317
[7]   How are neurons specified: master or positional control? [J].
Goetz, M .
TRENDS IN NEUROSCIENCES, 1998, 21 (04) :135-136
[8]   SOX2 functions to maintain neural progenitor identity [J].
Graham, V ;
Khudyakov, J ;
Ellis, P ;
Pevny, L .
NEURON, 2003, 39 (05) :749-765
[9]  
HACK MA, 2005, NATURE, V8
[10]   Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb [J].
Kohwi, M ;
Osumi, N ;
Rubenstein, JLR ;
Alvarez-Buylla, A .
JOURNAL OF NEUROSCIENCE, 2005, 25 (30) :6997-7003
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