Profiling breast cancer by array CGH

被引：78

作者：

Albertson, DG ^{[1
]}

机构：

[1] Univ Calif San Francisco, Ctr Comprehens Canc, San Francisco, CA 94143 USA

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2003年 / 78卷 / 03期

关键词：

array CGH; copy number aberration; genome instability;

D O I：

10.1023/A:1023025506386

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast tumors display a wide variety of genomic alterations. This review focuses on DNA copy number variations in these tumors as measured by the recently developed microarray-based form of comparative genomic hybridization. The capabilities of this new technology are reviewed. Initial applications of array CGH to the analysis of breast cancer, and the mechanisms by which the particular types of copy number changes might arise are discussed.

引用

页码：289 / 298

页数：10

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