The role of CD4+ T helper cells in the cytotoxic T lymphocyte response to HIV-1

被引：125

作者：

Altfeld, M

Rosenberg, ES

机构：

[1] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Charlestown, MA 02114 USA

[2] Harvard Univ, Sch Med, Charlestown, MA 02114 USA

[3] Massachusetts Gen Hosp, Infect Dis Unit, Boston, MA 02114 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(00)00103-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Virus-specific CD4(+) T cell help and CD8(+) cytotoxic T cell (CTL) responses are critical for the maintenance of effective immunity in chronic viral infections. HIV-1 infection presents a unique situation in which HIV-l-specific T helper cell responses are characteristically impaired and virus-specific CTLs wane over time as disease progresses; a relationship exists between T cell help and Cn responses in HIV-1 infection.

引用

收藏

页码：375 / 380

页数：6

相关论文

共 63 条

[1] T4+ T-HELPER CELL-FUNCTION INVIVO - DIFFERENTIAL REQUIREMENT FOR INDUCTION OF ANTIVIRAL CYTO-TOXIC T-CELL AND ANTIBODY-RESPONSES [J].

AHMED, R ;

BUTLER, LD ;

BHATTI, L .

JOURNAL OF VIROLOGY, 1988, 62 (06) :2102-2106

[2] Phenotypic analysis of antigen-specific T lymphocytes [J].

Altman, JD ;

Moss, PAH ;

Goulder, PJR ;

Barouch, DH ;

McHeyzerWilliams, MG ;

Bell, JI ;

McMichael, AJ ;

Davis, MM .

SCIENCE, 1996, 274 (5284) :94-96

[3] ENHANCED ESTABLISHMENT OF A VIRUS CARRIER STATE IN ADULT CD4+ T-CELL-DEFICIENT MICE [J].

BATTEGAY, M ;

MOSKOPHIDIS, D ;

RAHEMTULLA, A ;

HENGARTNER, H ;

MAK, TW ;

ZINKERNAGEL, RM .

JOURNAL OF VIROLOGY, 1994, 68 (07) :4700-4704

[4] ANTIGENIC PEPTIDES RECOGNIZED BY LYMPHOCYTES-T FROM AIDS VIRAL ENVELOPE-IMMUNE HUMANS [J].

BERZOFSKY, JA ;

BENSUSSAN, A ;

CEASE, KB ;

BOURGE, JF ;

CHEYNIER, R ;

LURHUMA, Z ;

SALAUN, JJ ;

GALLO, RC ;

SHEARER, GM ;

ZAGURY, D .

NATURE, 1988, 334 (6184) :706-708

[5] VIRUS-SPECIFIC CD8+ CYTOTOXIC T-LYMPHOCYTE ACTIVITY ASSOCIATED WITH CONTROL OF VIREMIA IN PRIMARY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION [J].

BORROW, P ;

LEWICKI, H ;

HAHN, BH ;

SHAW, GM ;

OLDSTONE, MBA .

JOURNAL OF VIROLOGY, 1994, 68 (09) :6103-6110

[6] T lymphocyte responses in HIV-1 infection: implications for vaccine development [J].

Brander, C ;

Walker, B .

CURRENT OPINION IN IMMUNOLOGY, 1999, 11 (04) :451-459

[7] Progressive loss of CD8(+) T cell-mediated control of a gamma-herpesvirus in the absence of CD4(+) T cells [J].

Cardin, RD ;

Brooks, JW ;

Sarawar, SR ;

Doherty, PC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (03) :863-871

[8] Priming of human CD4(+) antigen-specific T cells to undergo apoptosis by HIV-infected monocytes - A two-step mechanism involving the gp120 molecule [J].

Cottrez, F ;

Manca, F ;

Dalgleish, AG ;

ArenzanaSeisdedos, F ;

Capron, A ;

Groux, H .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (02) :257-266

[9] Evolution of cytotoxic T lymphocyte responses to human immunodeficiency virus type 1 in patients with symptomatic primary infection receiving antiretroviral triple therapy [J].

Dalod, M ;

Harzic, M ;

Pellegrin, I ;

Dumon, B ;

Hoen, B ;

Sereni, D ;

Deschemin, JC ;

Levy, JP ;

Venet, A ;

Gomard, E .

JOURNAL OF INFECTIOUS DISEASES, 1998, 178 (01) :61-69

[10] Weak anti-HIV CD8+ T-cell effector activity in HIV primary infection [J].

Dalod, M ;

Dupuis, M ;

Deschemin, JG ;

Goujard, C ;

Deveau, C ;

Meyer, L ;

Ngo, N ;

Rouzioux, C ;

Guillet, JG ;

Delfraissy, JF ;

Sinet, M ;

Venet, A .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (10) :1431-1439

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