Apoptosis - Death cycle and Swiss army knives

被引：97

作者：

Hengartner, MO ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

NATURE | 1998年 / 391卷 / 6666期

关键词：

D O I：

10.1038/35036

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

When a cell starts to undergo programmed cell death, cytochromec moves from the mitochondria, where it usually acts in an electron-transfer chain, to the cytosol. One of the relatively recent dogmas of apoptosis is that the death-suppressing protein Bcl-2 acts before cytochrome c in this pathway. But two new papers could overturn this dogma, by showing that Bcl-2 can also protect cells after cytochrome chas been released.

引用

页码：441 / 442

页数：2

共 13 条

[1] X-linked IAP is a direct inhibitor of cell-death proteases [J].

Deveraux, QL ;

Takahashi, R ;

Salvesen, GS ;

Reed, JC .

NATURE, 1997, 388 (6639) :300-304

[2] Human IAP-like protein regulates programmed cell death downstream of Bcl-xL and cytochrome c [J].

Duckett, CS ;

Li, F ;

Wang, Y ;

Tomaselli, KJ ;

Thompson, CB ;

Armstrong, RC .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (01) :608-615

[3] A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD [J].

Enari, M ;

Sakahira, H ;

Yokoyama, H ;

Okawa, K ;

Iwamatsu, A ;

Nagata, S .

NATURE, 1998, 391 (6662) :43-50

[4] Controlling cell death [J].

Golstein, P .

SCIENCE, 1997, 275 (5303) :1081-1082

[5] Apoptosis - CED-4 is a stranger no more [J].

Hengartner, MO .

NATURE, 1997, 388 (6644) :714-715

[6] The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis [J].

Kluck, RM ;

BossyWetzel, E ;

Green, DR ;

Newmeyer, DD .

SCIENCE, 1997, 275 (5303) :1132-1136

[7] Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade [J].

Li, P ;

Nijhawan, D ;

Budihardjo, I ;

Srinivasula, SM ;

Ahmad, M ;

Alnemri, ES ;

Wang, XD .

CELL, 1997, 91 (04) :479-489

[8] Cytochrome c: Can't live with it - Can't live without it [J].

Reed, JC .

CELL, 1997, 91 (05) :559-562

[9] Double identity for proteins of the Bcl-2 family [J].

Reed, JC .

NATURE, 1997, 387 (6635) :773-776

[10] Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c [J].

Rossé, T ;

Olivier, R ;

Monney, L ;

Rager, M ;

Conus, S ;

Fellay, I ;

Jansen, B ;

Borner, C .

NATURE, 1998, 391 (6666) :496-499

← 1 2 →