Ageing is associated in females with a decline in the content and activity of the b-c(1) complex in skeletal muscle mitochondria

被引：41

作者：

Boffoli, D

Scacco, SC

Vergari, R

Persio, MT

Solarino, G

Laforgia, R

Papa, S

机构：

[1] UNIV BARI,INST MED BIOCHEM & CHEM,I-70124 BARI,ITALY

[2] UNIV BARI,ORTHOPAED CLIN,BARI,ITALY

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 1996年 / 1315卷 / 01期

关键词：

ageing; mitochondrial respiration; respiratory chain; ubiquinol-cytochrome-c reductase; cytochrome-c oxidase; cytochrome;

D O I：

10.1016/0925-4439(95)00107-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The activity of cytochrome-c oxidase [E.C. 1.9.3.1] and b-c(1) complex [E.C. 1.10.2.2.] and the content of cytochromes 6, c + c(1) and a + a(3) in human skeletal muscle mitochondria from orthopaedic patients (108 women and 68 males), of age ranging between 10 and 90 years, have been analyzed. The activity of cytochrome c-oxidase declines with age both in females and males, The activity of b-c(1) complex, which in young females is significantly higher than in young malts, declines sharply in females, but not in males, with ageing. These results reveal that the content of active b-c(1) complex in muscle mitochondria is specifically controlled by female sex hormones.

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收藏

页码：66 / 72

页数：7

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