Molecular pathways of angiogenesis inhibition

被引：83

作者：

Tabruyn, Sebastien P. ^{[1
]}

Griffioen, Arjan W. ^{[1
]}

机构：

[1] Univ Maastricht, Res Inst Growth & Dev GROW, Dept Pathol, Angiogenesis Lab, NL-6202 AZ Maastricht, Netherlands

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 355卷 / 01期

关键词：

angiogenesis; angiostatic agent; signaling; endostatin; angiostatin; tumstatin; PF4; 16K hPRL; apoptosis; proliferation; migration;

D O I：

10.1016/j.bbrc.2007.01.123

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A large body of evidence now demonstrates that angiostatic therapy represents a promising way to fight cancer. This research recently resulted in the approval of the first angiostatic agent for clinical treatment of cancer. Progress has been achieved in decrypting the cellular signaling in endothelial cells induced by angiostatic agents. These agents predominantly interfere with the molecular pathways involved in migration, proliferation and endothelial cell survival. In the current review, these pathways are discussed. A thorough understanding of the mechanism of action of angiostatic agents is required to develop efficient anti-tumor therapies. (c) 2007 Elsevier Inc. All rights reserved.

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页码：1 / 5

页数：5

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