The many HATs of transcription coactivators

被引：289

作者：

Brown, CE ^{[1
]}

Lechner, T ^{[1
]}

Howe, L ^{[1
]}

Workman, JL ^{[1
]}

机构：

[1] Penn State Univ, Dept Biochem & Mol Biol, Howard Hughes Med Inst, University Pk, PA 16802 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 01期

关键词：

D O I：

10.1016/S0968-0004(99)01516-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone acetylation is closely linked to gene transcription. The identification of histone acetyltransferases (HATs) and the large multiprotein complexes in which they reside has yielded important insights into how these enzymes regulate transcription. The demonstration that HAT complexes interact with sequence-specific activator proteins illustrates how these complexes target specific genes. In addition to histones, some HATs can acetylate nonhistone proteins suggesting multiple roles for these enzymes.

引用

页码：15 / 19

页数：5

共 54 条

[31] The bromodomain of Gcn5p interacts in vitro with specific residues in the N terminus of histone H4 [J].

Ornaghi, P ;

Ballario, P ;

Lena, AM ;

Gonzàlez, A ;

Filetici, P .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 287 (01) :1-7

[32] Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-β promoter [J].

Parekh, BS ;

Maniatis, T .

MOLECULAR CELL, 1999, 3 (01) :125-129

[33] Mutations in chromatin components suppress a defect of Gcn5 protein in Saccharomyces cerevisiae [J].

Pérez-Martín, J ;

Johnson, AD .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (02) :1049-1054

[34] Role for ADA/GCN5 products in antagonizing chromatin-mediated transcriptional repression [J].

Pollard, KJ ;

Peterson, CL .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (11) :6212-6222

[35] Differential roles of p300 and PCAF acetyltransferases in muscle differentiation [J].

Puri, PL ;

Sartorelli, V ;

Yang, XJ ;

Hamamori, Y ;

Ogryzko, VV ;

Howard, BH ;

Kedes, L ;

Wang, JYJ ;

Graessmann, A ;

Nakatani, Y ;

Levrero, M .

MOLECULAR CELL, 1997, 1 (01) :35-45

[36]

Roberts SM, 1997, GENETICS, V147, P451

[37] Gcn5p is involved in the acetylation of histone H3 in nucleosomes [J].

RuizGarcia, AB ;

Sendra, R ;

Pamblanco, M ;

Tordera, V .

FEBS LETTERS, 1997, 403 (02) :186-190

[38] DNA damage activates p53 through a phosphorylation-acetylation cascade [J].

Sakaguchi, K ;

Herrera, JE ;

Saito, S ;

Miki, T ;

Bustin, M ;

Vassilev, A ;

Anderson, CW ;

Appella, E .

GENES & DEVELOPMENT, 1998, 12 (18) :2831-2841

[39] Identification of native complexes containing the yeast coactivator/repressor proteins NGG1/ADA3 and ADA2 [J].

Saleh, A ;

Lang, V ;

Cook, R ;

Brandl, CJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (09) :5571-5578

[40] Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates [J].

Schiltz, RL ;

Mizzen, CA ;

Vassilev, A ;

Cook, RG ;

Allis, CD ;

Nakatani, Y .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (03) :1189-1192

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