Molecular portraits and the family tree of cancer

被引：208

作者：

Chung, CH

Bernard, PS

Perou, CM

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Genet, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Pathol & Lab Med, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Div Hematol Oncol, Chapel Hill, NC 27599 USA

[4] Univ Utah, Huntsman Canc Inst, Dept Pathol, Salt Lake City, UT 84112 USA

来源：

NATURE GENETICS | 2002年 / 32卷 / Suppl 4期

关键词：

D O I：

10.1038/ng1038

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The twenty-first century heralds a new era for the biological sciences and medicine. The tools of our time are allowing us to analyze complex genomes more comprehensively than ever before. A principal technology contributing to this explosion of information is the DNA microarray, which enables us to study genome-wide expression patterns in complex biological systems. Although the potential of microarrays is yet to be fully realized, these tools have shown great promise in deciphering complex diseases such as cancer. The early results are painting a detailed portrait of cancer that illustrates the individuality of each tumor and allows familial relationships to be recognized through the identification of cell types sharing common expression patterns.

引用

页码：533 / 540

页数：8

共 50 条

[31]

Rickman DS, 2001, CANCER RES, V61, P6885

[32] The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma [J].

Rosenwald, A ;

Wright, G ;

Chan, WC ;

Connors, JM ;

Campo, E ;

Fisher, RI ;

Gascoyne, RD ;

Muller-Hermelink, HK ;

Smeland, EB ;

Staudt, LM .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (25) :1937-1947

[33] Systematic variation in gene expression patterns in human cancer cell lines [J].

Ross, DT ;

Scherf, U ;

Eisen, MB ;

Perou, CM ;

Rees, C ;

Spellman, P ;

Iyer, V ;

Jeffrey, SS ;

Van de Rijn, M ;

Waltham, M ;

Pergamenschikov, A ;

Lee, JCE ;

Lashkari, D ;

Shalon, D ;

Myers, TG ;

Weinstein, JN ;

Botstein, D ;

Brown, PO .

NATURE GENETICS, 2000, 24 (03) :227-235

[34] Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning [J].

Shipp, MA ;

Ross, KN ;

Tamayo, P ;

Weng, AP ;

Kutok, JL ;

Aguiar, RCT ;

Gaasenbeek, M ;

Angelo, M ;

Reich, M ;

Pinkus, GS ;

Ray, TS ;

Koval, MA ;

Last, KW ;

Norton, A ;

Lister, TA ;

Mesirov, J ;

Neuberg, DS ;

Lander, ES ;

Aster, JC ;

Golub, TR .

NATURE MEDICINE, 2002, 8 (01) :68-74

[35] Gene expression correlates of clinical prostate cancer behavior [J].

Singh, D ;

Febbo, PG ;

Ross, K ;

Jackson, DG ;

Manola, J ;

Ladd, C ;

Tamayo, P ;

Renshaw, AA ;

D'Amico, AV ;

Richie, JP ;

Lander, ES ;

Loda, M ;

Kantoff, PW ;

Golub, TR ;

Sellers, WR .

CANCER CELL, 2002, 1 (02) :203-209

[36] From patterns to pathways: gene expression data analysis comes of age [J].

Slonim, DK .

NATURE GENETICS, 2002, 32 (Suppl 4) :502-508

[37] Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications [J].

Sorlie, T ;

Perou, CM ;

Tibshirani, R ;

Aas, T ;

Geisler, S ;

Johnsen, H ;

Hastie, T ;

Eisen, MB ;

van de Rijn, M ;

Jeffrey, SS ;

Thorsen, T ;

Quist, H ;

Matese, JC ;

Brown, PO ;

Botstein, D ;

Lonning, PE ;

Borresen-Dale, AL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (19) :10869-10874

[38]

Su AI, 2001, CANCER RES, V61, P7388

[39] Gene expression profiling of clear cell renal cell carcinoma: Gene identification and prognostic classification [J].

Takahashi, M ;

Rhodes, DR ;

Furge, KA ;

Kanayamat, H ;

Kagawa, S ;

Haab, BB ;

Teh, BT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (17) :9754-9759

[40] Diagnosis of multiple cancer types by shrunken centroids of gene expression [J].

Tibshirani, R ;

Hastie, T ;

Narasimhan, B ;

Chu, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (10) :6567-6572

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