Mitochondrial control of cell death

被引：2736

作者：

Kroemer, G

Reed, JC

机构：

[1] Inst Gustave Roussy, CNRS, ULR 1599, F-94805 Villejuif, France

[2] Burnham Inst, La Jolla, CA 92037 USA

来源：

NATURE MEDICINE | 2000年 / 6卷 / 05期

关键词：

D O I：

10.1038/74994

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In many instances, permeabilization of mitochondrial membranes is a rate-limiting step of apoptotic or necrotic cell demise. This has important consequences for the pathophysiology of cell death, as well as for its pharmacological control.

引用

页码：513 / 519

页数：7

共 83 条

[61] Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-XL -: A potential role in modulating the threshold of cell death [J].

Passer, BJ ;

Pellegrini, L ;

Vito, P ;

Ganjei, JK ;

D'Adamio, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (34) :24007-24013

[62] Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore [J].

Pastorino, JG ;

Tafani, M ;

Rothman, RJ ;

Marcineviciute, A ;

Hoek, JB ;

Farber, JL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (44) :31734-31739

[63] Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition [J].

Patterson, SD ;

Spahr, CS ;

Daugas, E ;

Susin, SA ;

Irinopoulou, T ;

Koehler, C ;

Kroemer, G .

CELL DEATH AND DIFFERENTIATION, 2000, 7 (02) :137-144

[64]

PUTHALALATH G, 1999, MOL CELL, V3, P287

[65] Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore [J].

Ravagnan, L ;

Marzo, I ;

Costantini, P ;

Susin, SA ;

Zamzami, N ;

Petit, PX ;

Hirsch, F ;

Goulbern, M ;

Poupon, MF ;

Miccoli, L ;

Xie, ZH ;

Reed, JC ;

Kroemer, G .

ONCOGENE, 1999, 18 (16) :2537-2546

[66] A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation [J].

Rodrigues, CMP ;

Fan, GS ;

Ma, XM ;

Kren, BT ;

Steer, CJ .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (12) :2790-2799

[67] Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation [J].

Rodrigues, CMP ;

Ma, XM ;

Linehan-Stieers, C ;

Fan, GS ;

Kren, BT ;

Steer, CJ .

CELL DEATH AND DIFFERENTIATION, 1999, 6 (09) :842-854

[68] Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A [J].

Ruvolo, PP ;

Deng, XM ;

Ito, T ;

Carr, BK ;

May, WS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (29) :20296-20300

[69] Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization [J].

Sawa, A ;

Wiegand, GW ;

Cooper, J ;

Margolis, RL ;

Sharp, AH ;

Lawler, JF ;

Greenamyre, JT ;

Snyder, SH ;

Ross, CA .

NATURE MEDICINE, 1999, 5 (10) :1194-1198

[70] Apoptosis signaling in lymphocytes [J].

Scaffidi, C ;

Kirchhoff, S ;

Krammer, PH ;

Peter, ME .

CURRENT OPINION IN IMMUNOLOGY, 1999, 11 (03) :277-285

← 1 2 3 4 5 6 7 8 9 →