Validating survivin as a cancer therapeutic target

被引：1060

作者：

Altieri, DC ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Canc Biol, Worcester, MA 01605 USA

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 01期

关键词：

D O I：

10.1038/nrc968

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acquisition of the ability to evade cellular suicide, or apoptosis, is one of the master switches that contributes to cellular transformation and, ultimately, to invasive cancer. Much has been learned about the molecular organization of apoptotic pathways and their regulators, but the identification and validation of translational targets for apoptosis-based cancer therapy has posed a great challenge. Survivin is an attractive candidate for cancer therapy, so what is its potential applicability in the clinic?.

引用

页码：46 / 54

页数：9

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