Neuroprotection against oxidative stress by estrogens: Structure-activity relationship

被引：670

作者：

Behl, C ^{[1
]}

Skutella, T ^{[1
]}

Lezoualch, F ^{[1
]}

Post, A ^{[1
]}

Widmann, M ^{[1
]}

Newton, CJ ^{[1
]}

Holsboer, F ^{[1
]}

机构：

[1] INST ANAT,D-10098 BERLIN,GERMANY

来源：

MOLECULAR PHARMACOLOGY | 1997年 / 51卷 / 04期

关键词：

D O I：

10.1124/mol.51.4.535

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oxidative stress-induced neuronal cell death has been implicated in different neurological disorders and neurodegenerative diseases; one such ailment is Alzheimer's disease. Using the Alzheimer's disease-associated amyloid beta protein, glutamate, hydrogen peroxide, and buthionine sulfoximine, we investigated the neuroprotective potential of estrogen against oxidative stress-induced cell death. We show that 17-beta-estradiol, its nonestrogenic stereoisomer, 17-alpha-estradiol, and same estradiet derivatives can prevent intracellular peroxide accumulation and, ultimately, the degeneration of primary neurons, clonal hippocampal cells, and cells in organotypic hippocampal slices. The neuroprotective antioxidant activity of estrogens is dependent on the presence of the hydroxyl group in the C3 position on the A ring of the steroid molecule but is independent of an activation of estrogen receptors.

引用

页码：535 / 541

页数：7

共 31 条

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