PROTEIN-KINASE-C ACTIVATION INHIBITS GLUTAMATE-INDUCED CYTOTOXICITY IN A NEURONAL CELL-LINE

被引：312

作者：

DAVIS, JB ^{[1
]}

MAHER, P ^{[1
]}

机构：

[1] SALK INST BIOL RES,LA JOLLA,CA 92037

来源：

BRAIN RESEARCH | 1994年 / 652卷 / 01期

基金：

美国国家卫生研究院;

关键词：

12-O-TETRADECANOYLPHORBOL-13-ACETATE; NEUROTOXICITY; OXIDATIVE STRESS; GLUTATHIONE; ANTIOXIDANT;

D O I：

10.1016/0006-8993(94)90334-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A neuronal cell line, HT-22, is sensitive to glutamate cytotoxicity via a non-receptor mediated oxidative pathway. 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C, blocks this glutamate-induced cell death. Down-regulation of protein kinase C eliminates the protection against glutamate cytotoxicity afforded by TPA. The data suggest that protein kinase C activation blocks an early step in the cytotoxic pathway.

引用

收藏

页码：169 / 173

页数：5

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