Mammalian iron transport

被引:274
作者
Anderson, Gregory Jon [1 ]
Vulpe, Christopher D. [2 ]
机构
[1] PO Royal Brisbane Hosp, Queensland Inst Med Res, Iron Metab Lab, Brisbane, Qld 4029, Australia
[2] Univ Calif Berkeley, Dept Nutr Sci & Toxicol, Berkeley, CA 94720 USA
基金
英国医学研究理事会;
关键词
Iron transport; Transferrin; DMT1; Ferroportin; Hepcidin; Heme transport; Iron oxidoreductase; TRANSFERRIN-BOUND IRON; ANTIMICROBIAL PEPTIDE HEPCIDIN; HUMAN HEPATOMA-CELLS; NATURAL-RESISTANCE; REGULATORY PROTEINS; RAT HEPATOCYTES; NEURODEGENERATIVE DISEASE; DIFERRIC TRANSFERRIN; MACROPHAGE PROTEIN-1; TISSUE DISTRIBUTION;
D O I
10.1007/s00018-009-0051-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Iron is essential for basic cellular processes but is toxic when present in excess. Consequently, iron transport into and out of cells is tightly regulated. Most iron is delivered to cells bound to plasma transferrin via a process that involves transferrin receptor 1, divalent metal-ion transporter 1 and several other proteins. Non-transferrin-bound iron can also be taken up efficiently by cells, although the mechanism is poorly understood. Cells can divest themselves of iron via the iron export protein ferroportin in conjunction with an iron oxidase. The linking of an oxidoreductase to a membrane permease is a common theme in membrane iron transport. At the systemic level, iron transport is regulated by the liver-derived peptide hepcidin which acts on ferroportin to control iron release to the plasma.
引用
收藏
页码:3241 / 3261
页数:21
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