Iron metabolism meets signal transduction

被引：22

作者：

Anderson, GJ ^{[1
]}

Frazer, DM ^{[1
]}

机构：

[1] PO Royal Brisbane Hosp, Queensland Inst Med Res, Iron Metab Lab, Brisbane, Qld 4029, Australia

来源：

NATURE GENETICS | 2006年 / 38卷 / 05期

关键词：

D O I：

10.1038/ng0506-503

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mutations in hemojuvelin disrupt its ability to stimulate expression of the iron regulatory peptide hepcidin and result in the severe iron loading disorder juvenile hemochromatosis. A new study shows that hemojuvelin acts through the multifunctional bone morphogenetic protein pathway to modulate hepcidin levels, providing new insights into communication within a key physiological pathway.

引用

页码：503 / 504

页数：2

共 15 条

[1] Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression [J].

Babitt, JL ;

Huang, FW ;

Wrighting, DM ;

Xia, Y ;

Sidis, Y ;

Samad, TA ;

Campagna, JA ;

Chung, RT ;

Schneyer, AL ;

Woolf, CJ ;

Andrews, NC ;

Lin, HY .

NATURE GENETICS, 2006, 38 (05) :531-539

[2] Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor [J].

Babitt, JL ;

Zhang, Y ;

Samad, TA ;

Xia, Y ;

Tang, J ;

Campagna, JA ;

Schneyer, AL ;

Woolf, CJ ;

Lin, HY .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (33) :29820-29827

[3] Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis [J].

Bridle, KR ;

Frazer, DM ;

Wilkins, SJ ;

Dixon, JL ;

Purdie, DM ;

Crawford, DHG ;

Subramaniam, VN ;

Powell, LW ;

Anderson, GJ ;

Ramm, GA .

LANCET, 2003, 361 (9358) :669-673

[4] Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders [J].

Camaschella, C .

BLOOD, 2005, 106 (12) :3710-3717

[5] Bone morphogenetic proteins [J].

Chen, D ;

Zhao, M ;

Mundy, GR .

GROWTH FACTORS, 2004, 22 (04) :233-241

[6] The orchestration of body iron intake: how and where do enterocytes receive their cues? [J].

Frazer, DM ;

Anderson, GJ .

BLOOD CELLS MOLECULES AND DISEASES, 2003, 30 (03) :288-297

[7] Iron imports. IV. Hepcidin and regulation of body iron metabolism [J].

Ganz, T ;

Nemeth, E .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2006, 290 (02) :G199-G203

[8] Regulation of hepcidin transcription by interleukin-1 and interleukin-6 [J].

Lee, P ;

Peng, HF ;

Gelbart, T ;

Wang, L ;

Beutler, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (06) :1906-1910

[9] Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin [J].

Lin, L ;

Goldberg, YP ;

Ganz, T .

BLOOD, 2005, 106 (08) :2884-2889

[10] Hepcidin is decreased in TFR2 hemochromatosis [J].

Nemeth, E ;

Roetto, A ;

Garozzo, G ;

Ganz, T ;

Camaschella, C .

BLOOD, 2005, 105 (04) :1803-1806

← 1 2 →