Topological characteristics of helical repeat proteins

被引:285
作者
Groves, MR [1 ]
Barford, D [1 ]
机构
[1] Univ Oxford, Dept Biochem, Lab Mol Biophys, Oxford OX1 3QU, England
关键词
D O I
10.1016/S0959-440X(99)80052-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The recent elucidation of protein structures based upon repeating amino acid motifs, including the armadillo motif, the HEAT motif and tetratricopeptide repeats, reveals that they belong to the class of helical repeat proteins, These proteins share the common property of being assembled from tandem repeats of an alpha-helical structural unit, creating extended superhelical structures that are ideally suited to create a protein recognition interface.
引用
收藏
页码:383 / 389
页数:7
相关论文
共 31 条
[1]   HEAT REPEATS IN THE HUNTINGTONS-DISEASE PROTEIN [J].
ANDRADE, MA ;
BORK, P .
NATURE GENETICS, 1995, 11 (02) :115-116
[2]   The structure of GABPα/β:: An ETS domain ankyrin repeat heterodimer bound to DNA [J].
Batchelor, AH ;
Piper, DE ;
de la Brousse, FC ;
McKnight, SL ;
Wolberger, C .
SCIENCE, 1998, 279 (5353) :1037-1041
[3]  
BENNETT V, 1992, J BIOL CHEM, V267, P8703
[4]   HUNDREDS OF ANKYRIN-LIKE REPEATS IN FUNCTIONALLY DIVERSE PROTEINS - MOBILE MODULES THAT CROSS PHYLA HORIZONTALLY [J].
BORK, P .
PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1993, 17 (04) :363-374
[5]   Crystal structure of the complex of the cyclin D dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d [J].
Brotherton, DH ;
Dhanaraj, V ;
Wick, S ;
Brizuela, L ;
Domaille, PJ ;
Volyanik, E ;
Xu, X ;
Parisini, E ;
Smith, BO ;
Archer, SJ ;
Serrano, M ;
Brenner, SL ;
Blundell, TL ;
Laue, ED .
NATURE, 1998, 395 (6699) :244-250
[6]   Structure of the Sec7 domain of the Arf exchange factor ARNO [J].
Cherfils, J ;
Ménétrey, J ;
Mathieu, M ;
La Bras, G ;
Robineau, S ;
Béraud-Dufour, S ;
Antonny, B ;
Chardin, P .
NATURE, 1998, 392 (6671) :101-105
[7]   Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin α [J].
Conti, E ;
Uy, M ;
Leighton, L ;
Blobel, G ;
Kuriyan, J .
CELL, 1998, 94 (02) :193-204
[8]   The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions [J].
Das, AK ;
Cohen, PTW ;
Barford, D .
EMBO JOURNAL, 1998, 17 (05) :1192-1199
[9]   An extensively modified version of MolScript that includes greatly enhanced coloring capabilities [J].
Esnouf, RM .
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 1997, 15 (02) :132-+
[10]   Structural basis for activation of ARF GTPase: Mechanisms of guanine nucleotide exchange and GTP-myristoyl switching [J].
Goldberg, J .
CELL, 1998, 95 (02) :237-248