HUNDREDS OF ANKYRIN-LIKE REPEATS IN FUNCTIONALLY DIVERSE PROTEINS - MOBILE MODULES THAT CROSS PHYLA HORIZONTALLY

被引：455

作者：

BORK, P ^{[1
]}

机构：

[1] MAX DELBRUCK CTR MOLEC MED,D-13125 BERLIN,GERMANY

来源：

PROTEINS-STRUCTURE FUNCTION AND GENETICS | 1993年 / 17卷 / 04期

关键词：

SEQUENCE ANALYSIS; HOMOLOGY SEARCH; ANK REPEAT; HORIZONTAL GENE TRANSFER; CELL CYCLE PROTEINS; TRANSCRIPTION FACTOR NF-KAPPA-B;

D O I：

10.1002/prot.340170405

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Based on pattern searches and systematic database screening, almost 650 different ankyrin-like (ANK) repeats from nearly all phyla have been identified; more than 150 of them are reported here for the first time. Their presence in functionally diverse proteins such as enzymes, toxins, and transcription factors strongly suggests domain shuffling, but their occurrence in prokaryotes and yeast excludes exon shuffling. The spreading mechanism remains unknown, but in at least three cases horizontal gene transfer appears to be involved. ANK repeats occur in at least four consecutive copies. The terminal repeats are more variable in sequence. One feature of the internal repeats is a predicted central hydrophobic alpha-helix, which is likely to interact with other repeats. The functions of the ankyrin-like repeats are compatible with a role in protein-protein interactions. (C) 1993 Wiley-Liss, Inc.

引用

页码：363 / 374

页数：12

共 51 条

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