Mechanisms and dynamics of nuclear lamina-genome interactions

被引：89

作者：

Amendola, Mario ^{[1
]}

van Steensel, Bas ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Gene Regulat, Amsterdam, Netherlands

来源：

CURRENT OPINION IN CELL BIOLOGY | 2014年 / 28卷

关键词：

A-TYPE LAMINS; AUTOINTEGRATION FACTOR BAF; TRANSCRIPTION FACTOR MOK2; MEMBRANE PROTEIN MAN1; EMBRYONIC STEM-CELLS; DEACETYLASE; HDAC3; EMERIN IN-VITRO; B RECEPTOR; SUBNUCLEAR LOCALIZATION; CHROMATIN ORGANIZATION;

D O I：

10.1016/j.ceb.2014.03.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The nuclear lamina (NL) interacts with the genomic DNA and is thought to influence chromosome organization and gene expression. Both DNA sequences and histone modifications are important for NL tethering of the genomic DNA. These interactions are dynamic in individual cells and can change during differentiation and development. Evidence is accumulating that the NL contributes to the repression of transcription. Advances in mapping, genome-editing and microscopy techniques are increasing our understanding of the molecular mechanisms involved in NL-genome interactions.

引用

收藏

页码：61 / 68

页数：8

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