From in vivo to in silico biology and back

被引：200

作者：

Di Ventura, Barbara ^{[1
]}

Lemerle, Caroline ^{[1
]}

Michalodimitrakis, Konstantinos ^{[1
]}

Serrano, Luis ^{[1
]}

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

来源：

NATURE | 2006年 / 443卷 / 7111期

关键词：

D O I：

10.1038/nature05127

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The massive acquisition of data in molecular and cellular biology has led to the renaissance of an old topic: simulations of biological systems. Simulations, increasingly paired with experiments, are being successfully and routinely used by computational biologists to understand and predict the quantitative behaviour of complex systems, and to drive new experiments. Nevertheless, many experimentalists still consider simulations an esoteric discipline only for initiates. Suspicion towards simulations should dissipate as the limitations and advantages of their application are better appreciated, opening the door to their permanent adoption in everyday research.

引用

页码：527 / 533

页数：7

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