Fc receptor signaling and trafficking: a connection for antigen processing

被引：101

作者：

Amigorena, S ^{[1
]}

Bonnerot, C ^{[1
]}

机构：

[1] Inst Curie, Sect Rech, INSERM, U520, F-75005 Paris, France

来源：

IMMUNOLOGICAL REVIEWS | 1999年 / 172卷

关键词：

D O I：

10.1111/j.1600-065X.1999.tb01372.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Most hematopoietic cells express a wide variety of receptors for the Fc portion of immunoglobulins (FcR) belonging to the immunoreceptor family FcRs are multichain complexes composed of ligand-binding alpha chains, which determine Ig binding, and signal tranduction subunits, bearing a conserved immunoreceptor tyrosine-based activation motif (ITAM). Besides signaling, most Fc gamma Rs also efficiently internalize antigen-antibodies complexes and thus induce efficient processing of antigens into peptides presented by major histocompatibility complex (MHC) class II molecules. Importantly, ITAMs and cytosolic effecters of cell signaling also determine Fc gamma R's endocytic transport and antigen presentation capacities.

引用

页码：279 / 284

页数：6

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