TRANSIENT ACCUMULATION OF NEW CLASS-II MHC MOLECULES IN A NOVEL ENDOCYTIC COMPARTMENT IN B-LYMPHOCYTES

被引：411

作者：

AMIGORENA, S ^{[1
]}

DRAKE, JR ^{[1
]}

WEBSTER, P ^{[1
]}

MELLMAN, I ^{[1
]}

机构：

[1] YALE UNIV, SCH MED, CTR CELL IMAGING, NEW HAVEN, CT 06520 USA

来源：

NATURE | 1994年 / 369卷 / 6476期

关键词：

D O I：

10.1038/369113a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Endocytosis of antigen by antigen-presenting cells results in the production of peptides that bind to newly synthesized class II molecules of the major histocompatibility complex. A new population of class II-enriched vesicles has been discovered in B lymphocytes that accumulate internalized antigen but are distinct from endosomes and lysosomes. These vesicles also transiently accumulate newly synthesized class II and class II-peptide complexes and appear to be a compartment specialized for the transport and loading of class II molecules.

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页码：113 / 120

页数：8

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