Warming-activated channels of warm-sensitive neurons in rat hypothalamic slices

被引：37

作者：

Hori, A ^{[1
]}

Minato, K ^{[1
]}

Kobayashi, S ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Informat, Dept Intelligence Sci & Technol, Div Biol Informat, Kyoto 6068501, Japan

来源：

NEUROSCIENCE LETTERS | 1999年 / 275卷 / 02期

关键词：

warm-sensitive neuron; hypothalamus; non-selective cation channel; thermostat; brain slice; patch clamp;

D O I：

10.1016/S0304-3940(99)00732-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In mammals, multiple thermostats in several brain areas, e.g. the preoptic area and anterior hypothalamus (POAH), may regulate core temperature. In these areas, warm-sensitive (WS) and cold-sensitive (CS) neurons have been recorded. In our previous study, we proposed that primary WS and CS neurons act as multiple thermostats having threshold temperatures as target temperatures of regulation. Here we investigated ionic basis of WS neurons in rat POAH slices with patch-clamp technique. In whole-cell current-clamp recordings, warming above threshold temperatures induced depolarization (receptor potential), leading to spike generation. Whole-cell voltage-clamp and cell-attached patch recordings indicated that warming-activated non-selective cation channels underlie the receptor potential and spike generation. We conclude that the warming-activated channel in primary WS neurons is a key factor of thermostats. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：93 / 96

页数：4

共 13 条

[11] THERMAL STIMULATION OF ELECTRICAL ACTIVITY OF SINGLE UNITS OF PREOPTIC REGION [J].