Toll receptors, CD14, and macrophage activation and deactivation by LPS

被引：450

作者：

Dobrovolskaia, MA ^{[1
]}

Vogel, SN ^{[1
]}

机构：

[1] Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD 20814 USA

来源：

MICROBES AND INFECTION | 2002年 / 4卷 / 09期

关键词：

Toll-like receptors (TLR); CD14; lipopolysaccharide (LPS); signal transduction; macrophage; endotoxin tolerance; septic shock; inflammation; cytokines;

D O I：

10.1016/S1286-4579(02)01613-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review will focus on the molecular mechanisms of macrophage activation and desensitization by bacterial lipopolysaccharide (LPS). The most recent advances in the understanding of the function of the LPS receptor complex and its role in the development of the septic shock syndrome and endotoxin tolerance will be discussed. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：903 / 914

页数：12

共 100 条

[81] Lipopolysaccharide tolerance in murine peritoneal macrophages induces downregulation of the lipopolysaccharide signal transduction pathway through mitogen-activated protein kinase and nuclear factor-κB cascades, but not lipopolysaccharide-incorporation steps [J].

Tominaga, K ;

Saito, S ;

Matsuura, M ;

Nakano, M .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1999, 1450 (02) :130-144

[82] A CD14-independent LPS receptor cluster [J].

Triantafilou, K ;

Triantafilou, M ;

Dedrick, RL .

NATURE IMMUNOLOGY, 2001, 2 (04) :338-345

[83] The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens [J].

Underhill, DM ;

Ozinsky, A ;

Hajjar, AM ;

Stevens, A ;

Wilson, CB ;

Bassetti, M ;

Aderem, A .

NATURE, 1999, 401 (6755) :811-815

[84] Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the Toll/interleukin-1 receptor signaling pathway in innate immune cells [J].

Vabulas, RM ;

Ahmad-Nejad, P ;

da Costa, C ;

Miethke, T ;

Kirschning, CJ ;

Häcker, H ;

Wagner, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (33) :31332-31339

[85]

VIRCA GD, 1989, J BIOL CHEM, V264, P21951

[86] Signal integration in lipopolysaccharide (LPS)-stimulated murine macrophages [J].

Vogel, S ;

Hirschfeld, MJ ;

Perera, PY .

JOURNAL OF ENDOTOXIN RESEARCH, 2001, 7 (03) :237-241

[87] Inhibitory κBα control of nuclear factor-κB is dysregulated in endotoxin tolerant macrophages [J].

Wahlstrom, K ;

Bellingham, J ;

Rodriguez, JL ;

West, MA .

SHOCK, 1999, 11 (04) :242-247

[88] PREVENTION OF ENDOTOXIN-SHOCK BY AN ANTIBODY AGAINST LEUKOCYTE INTEGRIN BETA(2) THROUGH INHIBITING PRODUCTION AND ACTION OF TNF [J].

WATANABE, SI ;

MUKAIDA, N ;

IKEDA, N ;

AKIYAMA, M ;

HARADA, A ;

NAKANISHI, I ;

NARIUCHI, H ;

WATANABE, Y ;

MATSUSHIMA, K .

INTERNATIONAL IMMUNOLOGY, 1995, 7 (07) :1037-1046

[89] Role of p52 (NF-κB2) in LPS tolerance in a human B cell line [J].

Wedel, A ;

Frankenberger, M ;

Sulski, G ;

Petersmann, I ;

Kuprash, D ;

Nedospasov, S ;

Ziegler-Heitbrock, HWL .

BIOLOGICAL CHEMISTRY, 1999, 380 (10) :1193-1199

[90] CHEMISCHE ERFORSCHUNG VON LIPOPOLYSACCHARIDEN GRAMNEGATIVER BAKTERIEN [J].

WESTPHAL, O ;

LUDERITZ, O .

ANGEWANDTE CHEMIE, 1954, 66 (13-1) :407-417

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