Toll receptors, CD14, and macrophage activation and deactivation by LPS

被引：450

作者：

Dobrovolskaia, MA ^{[1
]}

Vogel, SN ^{[1
]}

机构：

[1] Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD 20814 USA

来源：

MICROBES AND INFECTION | 2002年 / 4卷 / 09期

关键词：

Toll-like receptors (TLR); CD14; lipopolysaccharide (LPS); signal transduction; macrophage; endotoxin tolerance; septic shock; inflammation; cytokines;

D O I：

10.1016/S1286-4579(02)01613-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This review will focus on the molecular mechanisms of macrophage activation and desensitization by bacterial lipopolysaccharide (LPS). The most recent advances in the understanding of the function of the LPS receptor complex and its role in the development of the septic shock syndrome and endotoxin tolerance will be discussed. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：903 / 914

页数：12

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