Role of the Nuclear Lamina in Genome Organization and Gene Expression

被引：67

作者：

Peric-Hupkes, D. ^{[1
]}

van Steensel, B. ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Gene Regulat, NL-1066 CX Amsterdam, Netherlands

来源：

NUCLEAR ORGANIZATION AND FUNCTION | 2010年 / 75卷

关键词：

DROSOPHILA-MELANOGASTER; DNA-REPLICATION; STEM-CELLS; CHROMATIN; REORGANIZATION; TRANSCRIPTION; CHROMOSOMES; MEMBRANE; ENVELOPE; DYNAMICS;

D O I：

10.1101/sqb.2010.75.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nuclear lamina is a major structural component of metazoan nuclei that has long been thought to provide an anchoring site for interphase chromosomes and have a role in gene regulation. Recent genome-wide mapping studies and functional experimental data strongly support these roles of the nuclear lamina. Here, we discuss new insights into various aspects of genome-nuclear lamina interactions, with emphasis on the links with gene regulation and with dynamics during cellular differentiation.

引用

页码：517 / 524

页数：8

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