RNA interference: genetic wand and genetic watchdog

被引：244

作者：

Bosher, JM ^{[1
]}

Labouesse, M ^{[1
]}

机构：

[1] ULP, Inst Genet & Biol Mol & Cellulaire, CNRS, INSERM, F-67404 Illkirch Graffenstaden, France

来源：

NATURE CELL BIOLOGY | 2000年 / 2卷 / 02期

关键词：

D O I：

10.1038/35000102

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In many species, introduction of double-stranded RNA (dsRNA) induces potent and specific gene silencing, a phenomenon called RNA interference or RNAi. The apparently widespread nature of RNAi in eukaryotes, ranging from trypanosome to mouse, has sparked great interest from both applied and fundamental standpoints, Here we review the technical improvements being made to increase the experimental potential of this technique. We also discuss recent advances in uncovering the proteins that act during the RNAi process, discoveries that have revealed enticing links between transposition, transgene silencing and RNAi.

引用

页码：E31 / E36

页数：6

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