Genome sequence of the nematode C-elegans:: A platform for investigating biology

被引:3460
作者
不详
机构
[1] Washington Univ, Genome Sequencing Ctr, St Louis, MO 63108 USA
[2] Sanger Ctr, Hinxton CB10 1SA, Cambs, England
基金
美国国家科学基金会;
关键词
D O I
10.1126/science.282.5396.2012
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The 97-megabase genomic sequence of the nematode Caenorhabditis elegans reveals over 19,000 genes. More than 40 percent of the predicted protein products find significant matches in other organisms. There is a variety of repeated sequences, both local and dispersed. The distinctive distribution of some repeats and highly conserved genes provides evidence for a regional organization of the chromosomes.
引用
收藏
页码:2012 / 2018
页数:7
相关论文
共 56 条
[1]  
ALTSCHUL SF, 1990, J MOL BIOL, V215, P403, DOI 10.1006/jmbi.1990.9999
[2]  
[Anonymous], COMMUNICATION
[3]  
[Anonymous], UNPUB
[4]  
BARNES TM, 1995, GENETICS, V141, P159
[5]   The human genome: Organization and evolutionary history [J].
Bernardi, G .
ANNUAL REVIEW OF GENETICS, 1995, 29 :445-476
[6]   The complete genome sequence of Escherichia coli K-12 [J].
Blattner, FR ;
Plunkett, G ;
Bloch, CA ;
Perna, NT ;
Burland, V ;
Riley, M ;
ColladoVides, J ;
Glasner, JD ;
Rode, CK ;
Mayhew, GF ;
Gregor, J ;
Davis, NW ;
Kirkpatrick, HA ;
Goeden, MA ;
Rose, DJ ;
Mau, B ;
Shao, Y .
SCIENCE, 1997, 277 (5331) :1453-+
[7]   A new DNA sequence assembly program [J].
Bonfield, JK ;
Smith, KF ;
Staden, R .
NUCLEIC ACIDS RESEARCH, 1995, 23 (24) :4992-4999
[8]   Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii [J].
Bult, CJ ;
White, O ;
Olsen, GJ ;
Zhou, LX ;
Fleischmann, RD ;
Sutton, GG ;
Blake, JA ;
FitzGerald, LM ;
Clayton, RA ;
Gocayne, JD ;
Kerlavage, AR ;
Dougherty, BA ;
Tomb, JF ;
Adams, MD ;
Reich, CI ;
Overbeek, R ;
Kirkness, EF ;
Weinstock, KG ;
Merrick, JM ;
Glodek, A ;
Scott, JL ;
Geoghagen, NSM ;
Weidman, JF ;
Fuhrmann, JL ;
Nguyen, D ;
Utterback, TR ;
Kelley, JM ;
Peterson, JD ;
Sadow, PW ;
Hanna, MC ;
Cotton, MD ;
Roberts, KM ;
Hurst, MA ;
Kaine, BP ;
Borodovsky, M ;
Klenk, HP ;
Fraser, CM ;
Smith, HO ;
Woese, CR ;
Venter, JC .
SCIENCE, 1996, 273 (5278) :1058-1073
[9]   CLONING OF LARGE SEGMENTS OF EXOGENOUS DNA INTO YEAST BY MEANS OF ARTIFICIAL CHROMOSOME VECTORS [J].
BURKE, DT ;
CARLE, GF ;
OLSON, MV .
SCIENCE, 1987, 236 (4803) :806-812
[10]  
CHEE MS, 1990, CURR TOP MICROBIOL, V154, P125