Leptin receptor signaling in is required for normal body POW neurons weight homeostasis

被引：738

作者：

Balthasar, N

Coppari, R

McMinn, J

Liu, SM

Lee, CE

Tang, V

Kenny, CD

McGovern, RA

Chua, SC

Elmquist, JK

Lowell, BB

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med,Div Endocrinol, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA

[3] Columbia Univ, Dept Pediat, New York, NY 10032 USA

来源：

NEURON | 2004年 / 42卷 / 06期

关键词：

D O I：

10.1016/j.neuron.2004.06.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuroanatomical and electrophysiological studies have shown that hypothalamic POMC neurons are targets of the adipostatic hormone leptin. However, the physiological relevance of leptin signaling in these neurons has not yet been directly tested. Here, using the Cre/ IoxP system, we critically test the functional importance of leptin action on POMC neurons by deleting leptin receptors specifically from these cells in mice. Mice lacking leptin signaling in POMC neurons are mildly obese, hyperleptinemic, and have altered expression of hypothalamic neuropeptides. In summary, leptin receptors on POMC neurons are required but not solely responsible for leptin's regulation of body weight homeostasis.

引用

页码：983 / 991

页数：9

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