Protein folding mechanisms: new methods and emerging ideas

被引：112

作者：

Brockwell, DJ ^{[1
]}

Smith, DA

Radford, SE

机构：

[1] Univ Leeds, Sch Biochem & Mol Biol, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Leeds, Dept Phys & Astron, Leeds LS2 9JT, W Yorkshire, England

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2000年 / 10卷 / 01期

基金：

英国工程与自然科学研究理事会; 英国惠康基金; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1016/S0959-440X(99)00043-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the past year. advances in our understanding of folding mechanisms have been made through detailed experimental and theoretical studies of a number of proteins. The development of new methods has allowed the earliest events in folding to be probed and the measurement of folding at the level of individual molecules is now possible, opening the door to exciting new experiments.

引用

页码：16 / 25

页数：10

共 82 条

[1] Matching theory and experiment in protein folding [J].

Alm, E ;

Baker, D .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1999, 9 (02) :189-196

[2] Direct observation of fast protein folding: The initial collapse of apomyoglobin [J].

Ballew, RM ;

Sabelko, J ;

Gruebele, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (12) :5759-5764

[3] The speed limit for protein folding measured by triplet-triplet energy transfer [J].

Bieri, O ;

Wirz, J ;

Hellrung, B ;

Schutkowski, M ;

Drewello, M ;

Kiefhaber, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (17) :9597-9601

[4] High populations of non-native structures in the denatured state are compatible with the formation of the native folded state [J].

Blanco, FJ ;

Serrano, L ;

Forman-Kay, JD .

JOURNAL OF MOLECULAR BIOLOGY, 1998, 284 (04) :1153-1164

[5] Protein folding dynamics: Quantitative comparison between theory and experiment [J].

Burton, RE ;

Myers, JK ;

Oas, TG .

BIOCHEMISTRY, 1998, 37 (16) :5337-5343

[6] The Greek key protein apo-pseudoazurin folds through an obligate on-pathway intermediate [J].

Capaldi, AP ;

Ferguson, SJ ;

Radford, SE .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 286 (05) :1621-1632

[7] Mechanical and chemical unfolding of a single protein: A comparison [J].

Carrion-Vazquez, M ;

Oberhauser, AF ;

Fowler, SB ;

Marszalek, PE ;

Broedel, SE ;

Clarke, J ;

Fernandez, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (07) :3694-3699

[8] Effect of H helix destabilizing mutations on the kinetic and equilibrium folding of apomyoglobin [J].

Cavagnero, S ;

Dyson, HJ ;

Wright, PE .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 285 (01) :269-282

[9]

Chiti F, 1999, NAT STRUCT BIOL, V6, P1005

[10]

Chiti F, 1999, NAT STRUCT BIOL, V6, P380

← 1 2 3 4 5 6 7 8 9 →