Histone methylation: Dynamic or static?

被引：404

作者：

Bannister, AJ ^{[1
]}

Schneider, R ^{[1
]}

Kouzarides, T ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Wellcome Trust Canc Res UK Inst, Cambridge CB2 1QR, England

来源：

CELL | 2002年 / 109卷 / 07期

关键词：

D O I：

10.1016/S0092-8674(02)00798-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Methylation of histones mediates transcriptional silencing at heterochromatin sites and affects regulated transcription at euchromatic loci. So is the methyl group a permanent mark on histones, or can it be removed by an active process necessary for regulated gene expression?

引用

页码：801 / 806

页数：6

共 32 条

[11] Deimination of arginine residues in nucleophosmin/B23 and histones in HL-60 granulocytes [J].

Hagiwara, T ;

Nakashima, K ;

Hirano, H ;

Senshu, T ;

Yamada, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 290 (03) :979-983

[12] Characterization of the FAD-containing N-methyltryptophan oxidase from Escherichia coli [J].

Khanna, P ;

Jorns, MS .

BIOCHEMISTRY, 2001, 40 (05) :1441-1450

[13]

KIM S, 1964, J BIOL CHEM, V239, P3790

[14] Histone methylation in transcriptional control [J].

Kouzarides, T .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2002, 12 (02) :198-209

[15] Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins [J].

Lachner, M ;

O'Carroll, N ;

Rea, S ;

Mechtler, K ;

Jenuwein, T .

NATURE, 2001, 410 (6824) :116-120

[16] Crystal structure of the nucleosome core particle at 2.8 angstrom resolution [J].

Luger, K ;

Mader, AW ;

Richmond, RK ;

Sargent, DF ;

Richmond, TJ .

NATURE, 1997, 389 (6648) :251-260

[17] Rb targets histone H3 methylation and HP1 to promoters [J].

Nielsen, SJ ;

Schneider, R ;

Bauer, UM ;

Bannister, AJ ;

Morrison, A ;

O'Carroll, D ;

Firestein, R ;

Cleary, M ;

Jenuwein, T ;

Herrera, RE ;

Kouzarides, T .

NATURE, 2001, 412 (6846) :561-565

[18]

OGAWA T, 1989, J BIOL CHEM, V264, P10205

[19] EPSILON-ALKYLLYSINASE NEW ASSAY METHOD, PURIFICATION, AND BIOLOGICAL SIGNIFICANCE [J].

PAIK, WK ;

KIM, S .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1974, 165 (01) :369-378

[20] ENZYMATIC DEMETHYLATION OF CALF THYMUS HISTONES [J].

PAIK, WK ;

KIM, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1973, 51 (03) :781-788

← 1 2 3 4 →