Histone methylation: Dynamic or static?

被引：404

作者：

Bannister, AJ ^{[1
]}

Schneider, R ^{[1
]}

Kouzarides, T ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Wellcome Trust Canc Res UK Inst, Cambridge CB2 1QR, England

来源：

CELL | 2002年 / 109卷 / 07期

关键词：

D O I：

10.1016/S0092-8674(02)00798-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Methylation of histones mediates transcriptional silencing at heterochromatin sites and affects regulated transcription at euchromatic loci. So is the methyl group a permanent mark on histones, or can it be removed by an active process necessary for regulated gene expression?

引用

页码：801 / 806

页数：6

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