Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics

被引：11181

作者：

Hardy, J

Selkoe, DJ ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Neurol Dis, Boston, MA 02115 USA

[2] NIA, Neurogenet Lab, Bethesda, MD 20892 USA

来源：

SCIENCE | 2002年 / 297卷 / 5580期

关键词：

D O I：

10.1126/science.1072994

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It has been more than 10 years since it was first proposed that the neurodegeneration in Alzheimer's disease (AD) may be caused by deposition of amyloid β-peptide (Aβ) in plaques in brain tissue. According to the amyloid hypothesis, accumulation of Aβ in the brain is the primary influence driving AD pathogenesis. The rest of the disease process, including formation of neurofibrillary tangles containing tau protein, is proposed to result from an imbalance between Aβ production and Aβ clearance.

引用

页码：353 / 356

页数：4

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