Let-7 in Cardiovascular Diseases, Heart Development and Cardiovascular Differentiation from Stem Cells

被引：174

作者：

Bao, Mei-Hua ^{[1
,2
]}

Feng, Xing ^{[3
]}

Zhang, Yi-Wen ^{[1
]}

Lou, Xiao-Ya ^{[1
]}

Cheng, Yu ^{[1
]}

Zhou, Hong-Hao ^{[1
]}

机构：

[1] Cent South Univ, Inst Clin Pharmacol, Changsha 410078, Hunan, Peoples R China

[2] Changsha Med Univ, Dept Pharm, Changsha 410219, Hunan, Peoples R China

[3] Hunan Normal Univ, Coll Med, Changsha 410006, Hunan, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 11期

关键词：

let-7; cardiovascular disease; cardiovascular differentiation; heart development; biomarker; TO-MESENCHYMAL TRANSITION; MICRORNA EXPRESSION; CIRCULATING MICRORNAS; CHANNEL GENES; OX-LDL; RNA; DICER; TOLL-LIKE-RECEPTOR-4; ANGIOGENESIS; CONTRIBUTES;

D O I：

10.3390/ijms141123086

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The let-7 family is the second microRNA found in C. elegans. Recent researches have found it is highly expressed in the cardiovascular system. Studies have revealed the aberrant expression of let-7 members in cardiovascular diseases, such as heart hypertrophy, cardiac fibrosis, dilated cardiomyopathy (DCM), myocardial infarction (MI), arrhythmia, angiogenesis, atherosclerosis, and hypertension. Let-7 also participates in cardiovascular differentiation of embryonic stem cells. TLR4, LOX-1, Bcl-xl and AGO1 are by now the identified target genes of let-7. The circulating let-7b is suspected to be the biomarker of acute MI and let-7i, the biomarker of DCM. Further studies are necessary for identifying the gene targets and signaling pathways of let-7 in cardiovascular diseases. Let-7 might be a potential therapeutic target for cardiovascular diseases. This review focuses on the research progresses regarding the roles of let-7 in cardiovascular development and diseases.

引用

页码：23086 / 23102

页数：17

共 80 条

[71] MicroRNAs in the human heart - A clue to fetal gene reprogramming in heart failure [J].

Thum, Thomas ;

Galuppo, Paolo ;

Wolf, Christian ;

Fiedler, Jan ;

Kneitz, Susanne ;

van Laake, Linda W. ;

Doevendans, Pieter A. ;

Mummery, Christine L. ;

Borlak, Jurgen ;

Haverich, Axel ;

Gross, Carina ;

Engelhardt, Stefan ;

Ertl, Georg ;

Bauersachs, Johann .

CIRCULATION, 2007, 116 (03) :258-267

[72] Role of MicroRNAs in Cardiac Remodeling and Heart Failure [J].

Topkara, Veli K. ;

Mann, Douglas L. .

CARDIOVASCULAR DRUGS AND THERAPY, 2011, 25 (02) :171-182

[73] AngiomiRs-Key regulators of angiogenesis [J].

Wang, Shusheng ;

Olson, Eric N. .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2009, 19 (03) :205-211

[74] Circulating miRNAs as Potential Marker for Pulmonary Hypertension [J].

Wei, Chuanyu ;

Henderson, Heather ;

Spradley, Christopher ;

Li, Li ;

Kim, Il-Kwon ;

Kumar, Sandeep ;

Hong, Nayeon ;

Arroliga, Alejandro C. ;

Gupta, Sudhiranjan .

PLOS ONE, 2013, 8 (05)

[75] miR-125b Promotes Early Germ Layer Specification through Lin28/let-7d and Preferential Differentiation of Mesoderm in Human Embryonic Stem Cells [J].

Wong, Sharon S. Y. ;

Ritner, Carissa ;

Ramachandran, Sweta ;

Aurigui, Julian ;

Pitt, Cameron ;

Chandra, Piyanka ;

Ling, Vivian B. ;

Yabut, Odessa ;

Bernstein, Harold S. .

PLOS ONE, 2012, 7 (04)

[76] miR-296 Regulates Growth Factor Receptor Overexpression in Angiogenic Endothelial Cells [J].

Wuerdinger, Thomas ;

Tannous, Bakhos A. ;

Saydam, Okay ;

Skog, Johan ;

Grau, Stephan ;

Soutschek, Juergen ;

Weissleder, Ralph ;

Breakefield, Xandra O. ;

Krichevsky, Anna M. .

CANCER CELL, 2008, 14 (05) :382-393

[77] RETRACTED: MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts (Retracted Article) [J].

Xiao, Jiening ;

Luo, Xiaobin ;

Lin, Huixian ;

Zhang, Ying ;

Lu, Yanjie ;

Wang, Ning ;

Zhang, Yiqiang ;

Yang, Baofeng ;

Wang, Zhiguo .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (17) :12363-12367

[78] The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2 [J].

Yang, Baofeng ;

Lin, Huixian ;

Xiao, Jiening ;

Lu, Yanjie ;

Luo, Xiaobin ;

Li, Baoxin ;

Zhang, Ying ;

Xu, Chaoqian ;

Bai, Yunlong ;

Wang, Huizhen ;

Chen, Guohao ;

Wang, Zhiguo .

NATURE MEDICINE, 2007, 13 (04) :486-491

[79] Thioredoxin 1 Negatively Regulates Angiotensin II-Induced Cardiac Hypertrophy Through Upregulation of miR-98/let-7 [J].

Yang, Yanfei ;

Ago, Tetsuro ;

Zhai, Peiyong ;

Abdellatif, Maha ;

Sadoshima, Junichi .

CIRCULATION RESEARCH, 2011, 108 (03) :305-U102

[80] Endothelial-to-mesenchymal transition contributes to cardiac fibrosis [J].

Zeisberg, Elisabeth M. ;

Tarnavski, Oleg ;

Zeisberg, Michael ;

Dorfman, Adam L. ;

McMullen, Julie R. ;

Gustafsson, Erika ;

Chandraker, Anil ;

Yuan, Xueli ;

Pu, William T. ;

Roberts, Anita B. ;

Neilson, Eric G. ;

Sayegh, Mohamed H. ;

Izumo, Seigo ;

Kalluri, Raghu .

NATURE MEDICINE, 2007, 13 (08) :952-961

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