Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design

被引：454

作者：

Ladbury, JE

机构：

[1] Dept. of Biochem. and Molec. Biology, University College London, London W1P 8BT

来源：

CHEMISTRY & BIOLOGY | 1996年 / 3卷 / 12期

关键词：

D O I：

10.1016/S1074-5521(96)90164-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent data have highlighted the enigmatic role that water plays in biomolecular complexes. Water at the interface of a complex can increase the promiscuity of an interaction, yet it can also provide increased specificity and affinity. The ability to engineer water-binding sites into the interface between a drug and its target might prove useful in drug design. (C) Current Biology Ltd.

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页码：973 / 980

页数：8

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