Pathophysiology of anorexia

被引:32
作者
Morley, JE
机构
[1] St Louis Univ, Sch Med, Div Geriatr Med, St Louis, MO 63104 USA
[2] Vet Adm Med Ctr, Ctr Geriatr Res Educ & Clin, St Louis, MO 63104 USA
关键词
D O I
10.1016/S0749-0690(02)00047-2
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
A physiologic decline in food intake occurs with advancing age. The physiologic anorexia of aging and its associated weight loss predispose older persons to develop protein-energy malnutrition. In older persons a variety of social and psychologic factors, diseases, and medications can aggravate the physiologic anorexia and lead to severe weight loss. Many of these factors are amenable to treatment, resulting in a reversal of the underlying malnutrition. This article first reviews the physiologic factors responsible for anorexia in older persons. It then reviews the major pathologic processes responsible for producing protein-energy malnutrition in older persons.
引用
收藏
页码:661 / +
页数:14
相关论文
共 108 条
[71]   Anorexia of aging: physiologic and pathologic [J].
Morley, JE .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1997, 66 (04) :760-773
[72]   NEUROPEPTIDE REGULATION OF APPETITE AND WEIGHT [J].
MORLEY, JE .
ENDOCRINE REVIEWS, 1987, 8 (03) :256-287
[73]   β-Amyloid precursor polypeptide in SAMP8 mice affects learning and memory [J].
Morley, JE ;
Kumar, VB ;
Bernardo, AE ;
Farr, SA ;
Uezu, K ;
Tumosa, N ;
Flood, JF .
PEPTIDES, 2000, 21 (12) :1761-1767
[74]   NITRIC-OXIDE SYNTHASE INHIBITION AND FOOD-INTAKE - EFFECTS ON MOTIVATION TO EAT AND IN FEMALE MICE [J].
MORLEY, JE ;
FARR, SA ;
SUAREZ, MD ;
FLOOD, JF .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1995, 50 (03) :369-373
[75]   CORTICOTROPIN RELEASING-FACTOR, GROOMING AND INGESTIVE BEHAVIOR [J].
MORLEY, JE ;
LEVINE, AS .
LIFE SCIENCES, 1982, 31 (14) :1459-1464
[76]  
MORLEY JE, 2001, ANN LONG TERM CARE S, V2, P1
[77]  
Nelson K A, 1993, J Palliat Care, V9, P27
[78]   THE CANCER ANOREXIA-CACHEXIA SYNDROME [J].
NELSON, KA ;
WALSH, D ;
SHEEHAN, FA .
JOURNAL OF CLINICAL ONCOLOGY, 1994, 12 (01) :213-225
[79]   Assessment of protein energy malnutrition in older persons, part I: History, examination, body composition, and screening tools [J].
Omran, ML ;
Morley, JE .
NUTRITION, 2000, 16 (01) :50-63
[80]   Caloric restriction mimetics: Physical activity and body composition changes [J].
Poehlman, ET ;
Turturro, A ;
Bodkin, N ;
Cefalu, W ;
Heymsfield, S ;
Holloszy, J ;
Kemnitz, J .
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2001, 56 :45-54