Molecular characterization of the tumor microenvironment in breast cancer

被引：1066

作者：

Allinen, M

Beroukhim, R

Cai, L

Brennan, C

Lahti-Domenici, J

Huang, HY

Porter, D

Hu, M

Chin, L

Richardson, A

Schnitt, S

Sellers, WR

Polyak, K ^{[1
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Dana Farber Canc Inst, Dept Res Comp, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[6] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[7] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[8] Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02115 USA

[9] Harvard Univ, Broad Inst, Cambridge, MA 02142 USA

[10] Harvard Univ, MIT, Cambridge, MA 02142 USA

来源：

CANCER CELL | 2004年 / 6卷 / 01期

关键词：

D O I：

10.1016/j.ccr.2004.06.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Here we describe the comprehensive gene expression profiles of each cell type composing normal breast tissue and in situ and invasive breast carcinomas using serial analysis of gene expression. Based on these data, we determined that extensive gene expression changes occur in all cell types during cancer progression and that a significant fraction of altered genes encode secreted proteins and receptors. Despite the dramatic gene expression changes in all cell types, genetic alterations were detected only in cancer epithelial cells. The CXCL14 and CXCL12 chemokines overexpressed in tumor myoepithelial cells and myofibroblasts, respectively, bind to receptors on epithelial cells and enhance their proliferation, migration, and invasion. Thus, chemokines may play a role in breast tumorigenesis by acting as paracrine factors.

引用

页码：17 / 32

页数：16

共 95 条

[1] Myoepithelial-specific CD44 shedding contributes to the anti-invasive and antiangiogenic phenotype of myoepithelial cells [J].