Application of comparative genomic hybridization in search for genetic aberrations in fibroadenomas of the breast

被引：13

作者：

Amiel, A ^{[1
]}

Kaufman, Z

Goldstein, E

Bruchim, RBS

Kidron, D

Gaber, E

Fejgin, MD

机构：

[1] Meir Hosp, Inst Genet, IL-44281 Kefar Sava, Israel

[2] Bar Ilan Univ, Fac Life Sci, IL-52100 Ramat Gan, Israel

[3] Meir Hosp, Breast Hlth Unit, IL-44281 Kefar Sava, Israel

[4] Tel Aviv Univ, IL-69978 Tel Aviv, Israel

[5] Meir Hosp, Inst Pathol, IL-44281 Kefar Sava, Israel

来源：

CANCER GENETICS AND CYTOGENETICS | 2003年 / 142卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(02)00833-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We applied a comparative genomic hybridization (CGH) technique to paraffin-embedded tissue samples taken from fibroadenomas, benign breast tumors, to detect possible numerical and unbalanced genetic changes. We compared the results to those from previous cytogenetic studies of fibroadenomas. In concurrence with previous cytogenetic studies of fibroadenomas, we detected genetic aberrations in chromosomes 4-6, 8-13, 16, 18, 19, 20, and 22. In addition, with the CGH technique we were able to find two new aberrations, 15q+ and 16p-. Because these aberrations have also been reported to be present in breast cancer, the importance of this finding is yet to be determined. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：145 / 148

页数：4

共 41 条

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