Predictive value of S-100B protein and neuron specific-enolase as markers of traumatic brain damage in clinical use

被引：82

作者：

Naeimi, ZS ^{[1
]}

Weinhofer, A ^{[1
]}

Sarahrudi, K ^{[1
]}

Heinz, T ^{[1
]}

Vécsei, V ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Traumatol, A-1090 Vienna, Austria

来源：

BRAIN INJURY | 2006年 / 20卷 / 05期

关键词：

S100B; NSE; traumatic brain injury; Marshall;

D O I：

10.1080/02699050600664418

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objective: S-100B and NSE proteins are considered to be neurobiochemical markers for the brain damage. The aim of this study was to consider the diagnostic and prognostic validity of the initial serum levels of S-100B and NSE in clinical use. Methods: Forty-five patients with traumatic brain injury were included in this prospective study. Neurologic examination and CCT-scan were performed. S-100B and NSE were analysed. Patients were divided in two groups depending on the severity of injury. Results: The results showed a significant difference between the S-100B serum concentration and the two groups-minor head injuries and severe head injuries. A statistically significant correlation was observed between an increase of S-100B and NSE serum values and a cerebral pathological finding in CT scans. Conclusion: The clear correlation between S-100B and NSE serum concentrations and CCT findings does not validate both markers as an independent predictor of diagnosis and prognosis of brain injury.

引用

页码：463 / 468

页数：6

共 46 条

[21] ALCOHOL AND HEAD-INJURY - AN ISSUE REVISITED [J].

KELLY, DF .

JOURNAL OF NEUROTRAUMA, 1995, 12 (05) :883-890

[22] Studies of the brain specificity of S100B and neuron-specific enolase (NSE) in blood serum of acute care patients [J].

Kleine, TO ;

Benes, L ;

Zöfel, P .

BRAIN RESEARCH BULLETIN, 2003, 61 (03) :265-279

[23] Increased serum S100B protein in schizophrenia: a study in medication-free patients [J].

Lara, DR ;

Gama, CS ;

Belmonte-de-Abreu, P ;

Portela, LVC ;

Goncalves, CA ;

Fonseca, M ;

Hauck, S ;

Souza, DO .

JOURNAL OF PSYCHIATRIC RESEARCH, 2001, 35 (01) :11-14

[24]

MARSHALL LF, 1992, J NEUROTRAUMA, V9, P287

[25]

MIDDELBOE T, 1992, ACTA NEUROL SCAND, V85, P5

[26] A SOLUBLE PROTEIN CHARACTERISTIC OF NERVOUS SYSTEM [J].

MOORE, BW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1965, 19 (06) :739-&

[27] Immediate S-100B and neuron-specific enolase plasma measurements for rapid evaluation of primary brain damage in alcohol-intoxicated, minor head-injured patients [J].

Mussack, T ;

Biberthaler, P ;

Kanz, KG ;

Heckl, U ;

Gruber, R ;

Linsenmaier, U ;

Mutschler, W ;

Jochum, M .

SHOCK, 2002, 18 (05) :395-400

[28] Early cellular brain damage and systemic inflammatory response after cardiopulmonary resuscitation or isolated severe head trauma: a comparative pilot study on common pathomechanisms [J].

Mussack, T ;

Biberthaler, P ;

Gippner-Steppert, C ;

Kanz, KG ;

Wiedemann, E ;

Mutschler, W ;

Jochum, M .

RESUSCITATION, 2001, 49 (02) :193-199

[29] S-100β reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury [J].

Pleines, UE ;

Morganti-Kossmann, MC ;

Rancan, M ;

Joller, H ;

Trentz, O ;

Kossmann, T .

JOURNAL OF NEUROTRAUMA, 2001, 18 (05) :491-498

[30]

Portela LVC, 2002, CLIN CHEM, V48, P950

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