Predictive value of S-100B protein and neuron specific-enolase as markers of traumatic brain damage in clinical use

被引：82

作者：

Naeimi, ZS ^{[1
]}

Weinhofer, A ^{[1
]}

Sarahrudi, K ^{[1
]}

Heinz, T ^{[1
]}

Vécsei, V ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Traumatol, A-1090 Vienna, Austria

来源：

BRAIN INJURY | 2006年 / 20卷 / 05期

关键词：

S100B; NSE; traumatic brain injury; Marshall;

D O I：

10.1080/02699050600664418

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objective: S-100B and NSE proteins are considered to be neurobiochemical markers for the brain damage. The aim of this study was to consider the diagnostic and prognostic validity of the initial serum levels of S-100B and NSE in clinical use. Methods: Forty-five patients with traumatic brain injury were included in this prospective study. Neurologic examination and CCT-scan were performed. S-100B and NSE were analysed. Patients were divided in two groups depending on the severity of injury. Results: The results showed a significant difference between the S-100B serum concentration and the two groups-minor head injuries and severe head injuries. A statistically significant correlation was observed between an increase of S-100B and NSE serum values and a cerebral pathological finding in CT scans. Conclusion: The clear correlation between S-100B and NSE serum concentrations and CCT findings does not validate both markers as an independent predictor of diagnosis and prognosis of brain injury.

引用

页码：463 / 468

页数：6

共 46 条

[1]

Astudillo R, 1996, Eur J Cardiothorac Surg, V10, P1107, DOI 10.1016/S1010-7940(96)80358-7

[2] Evaluation of S-100b as a specific marker for neuronal damage due to minor head trauma [J].

Biberthaler, P ;

Mussack, T ;

Wiedemann, E ;

Kanz, KG ;

Koelsch, M ;

Gippner-Steppert, C ;

Jochum, M .

WORLD JOURNAL OF SURGERY, 2001, 25 (01) :93-97

[3] SERUM NEURON-SPECIFIC ENOLASE IN CHILDRENS CANCER [J].

COOPER, EH ;

PRITCHARD, J ;

BAILEY, CC ;

NINANE, J .

BRITISH JOURNAL OF CANCER, 1987, 56 (01) :65-67

[4] S100 and cognitive impairment after mild traumatic brain injury [J].

de Boussard, CN ;

Lundin, A ;

Karlstedt, D ;

Edman, G ;

Bartfai, A ;

Borg, J .

JOURNAL OF REHABILITATION MEDICINE, 2005, 37 (01) :53-57

[5] S-100B and neuron-specific enolase in serum of mild traumatic brain injury patients - A comparison with healthy controls [J].

de Kruijk, JR ;

Leffers, P ;

Menheere, PPCA ;

Meerhoff, S ;

Twijnstra, A .

ACTA NEUROLOGICA SCANDINAVICA, 2001, 103 (03) :175-179

[6] Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type [J].

Donato, R .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1999, 1450 (03) :191-231

[7]

GERBITZ KD, 1986, J CLIN CHEM CLIN BIO, V24, P1009

[8]

GERBITZ KD, 1989, TUMORDIAGN THER, V10, P45

[9] Ca2+-binding S100 proteins in the central nervous system [J].

Heizmann, CW .

NEUROCHEMICAL RESEARCH, 1999, 24 (09) :1097-1100

[10] Release of biochemical markers of damage to neuronal and glial brain tissue is associated with short and long term neuropsychological outcome after traumatic brain injury [J].

Herrmann, M ;

Curio, N ;

Jost, S ;

Grubich, C ;

Ebert, AD ;

Fork, ML ;

Synowitz, H .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2001, 70 (01) :95-100

← 1 2 3 4 5 →