Signaling mechanisms in the antimicrobial host defense of Drosophila

被引：179

作者：

Imler, JL ^{[1
]}

Hoffmann, JA ^{[1
]}

机构：

[1] Inst Biol Mol & Cellulaire, UPR 9022 CNRS, F-67084 Strasbourg, France

来源：

CURRENT OPINION IN MICROBIOLOGY | 2000年 / 3卷 / 01期

关键词：

D O I：

10.1016/S1369-5274(99)00045-4

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Drosophila has appeared in recent years as a powerful model to study innate immunity. Several papers published in the past year shed light on the role of the three Rel proteins Dorsal, Dif and Relish in the regulation of antimicrobial peptide expression. In addition, the discovery that a blood serine protease inhibitor is involved in the control of the antifungal response indicates that Toll is activated upon triggering of a proteolytic cascade and does not function as a Drosophila pattern recognition receptor.

引用

页码：16 / 22

页数：7

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