Heterogeneity in breast cancer and the problem of relevance of findings

被引:23
作者
Aubele, M
Werner, M
机构
[1] GSF Forschungszentrum Umwelt & Gesundheit GMBH, Inst Pathol, D-85764 Neuherberg, Germany
[2] Tech Univ Munich, Klinikum Rechts Isar, D-8000 Munich, Germany
来源
ANALYTICAL CELLULAR PATHOLOGY | 1999年 / 19卷 / 02期
关键词
D O I
10.1155/1999/960923
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Many attempts are made to identify critical genetic events responsible for the development and progression of breast cancer. There is increasing evidence that breast cancer is a heterogeneous disease, both, phenotypically as well as with respect to its molecular biologically. It is, therefore, extremely difficult to establish a diagnostically and prognostically relevant tumourigenesis model. Emerging new techniques such as microarrays, will provide us with a wealth of additional data over the next years. The precise sampling of tumour material in clearly defined histopathological lesions will be a prerequisite for the assignment of specific genetic alterations to defined stages of breast disease.
引用
收藏
页码:53 / 58
页数:6
相关论文
共 52 条
[41]  
RIED T, 1995, CANCER RES, V55, P5415
[42]   Microsatellite alterations indicating monoclonality in atypical hyperplasias associated with breast cancer [J].
Rosenberg, CL ;
Larson, PS ;
Romo, JD ;
DelasMorenas, A ;
Faller, DV .
HUMAN PATHOLOGY, 1997, 28 (02) :214-219
[43]   QUANTITATIVE MONITORING OF GENE-EXPRESSION PATTERNS WITH A COMPLEMENTARY-DNA MICROARRAY [J].
SCHENA, M ;
SHALON, D ;
DAVIS, RW ;
BROWN, PO .
SCIENCE, 1995, 270 (5235) :467-470
[44]  
Simpson JF, 1996, AM J PATHOL, V149, P751
[45]  
SolinasToldo S, 1997, GENE CHROMOSOME CANC, V20, P399, DOI 10.1002/(SICI)1098-2264(199712)20:4<399::AID-GCC12>3.0.CO
[46]  
2-I
[47]  
TAVASSOLI FA, 1990, CANCER, V65, P518, DOI 10.1002/1097-0142(19900201)65:3<518::AID-CNCR2820650324>3.0.CO
[48]  
2-O
[49]   CYTOGENETIC ANALYSIS OF MULTIFOCAL BREAST CARCINOMAS - DETECTION OF KARYOTYPICALLY UNRELATED CLONES AS WELL AS CLONAL SIMILARITIES BETWEEN TUMOR FOCI [J].
TEIXEIRA, MR ;
PANDIS, N ;
BARDI, G ;
ANDERSEN, JA ;
MANDAHL, N ;
MITELMAN, F ;
HEIM, S .
BRITISH JOURNAL OF CANCER, 1994, 70 (05) :922-927
[50]   CLONAL HETEROGENEITY IN BREAST-CANCER - KARYOTYPIC COMPARISONS OF MULTIPLE INTRA-TUMOROUS AND EXTRA-TUMOROUS SAMPLES FROM 3 PATIENTS [J].
TEIXEIRA, MR ;
PANDIS, N ;
BARDI, G ;
ANDERSEN, JA ;
MITELMAN, F ;
HEIM, S .
INTERNATIONAL JOURNAL OF CANCER, 1995, 63 (01) :63-68