Inosine induces axonal rewiring and improves behavioral outcome after stroke

被引：212

作者：

Chen, P

Goldberg, DE

Kolb, B

Lanser, M

Benowitz, LI

机构：

[1] Childrens Hosp, Dept Neurosurg, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Univ Lethbridge, Dept Psychol & Neurosci, Lethbridge, AB 11K 3M4, Canada

[4] Boston Life Sci Inc, Boston, MA 02116 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2002年 / 99卷 / 13期

关键词：

D O I：

10.1073/pnas.132076299

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cerebral infarct (stroke) often causes devastating and irreversible losses of function, in part because of the brain's limited capacity for anatomical reorganization. The purine nucleoside inosine has previously been shown to induce neurons to express a set of growth-associated proteins and to extend axons in culture and in vivo. We show here that in adult rats with unilateral cortical infarcts, inosine stimulated neurons on the undamaged side of the brain to extend new projections to denervated areas of the midbrain and spinal cord. This growth was paralleled by improved performance on several behavioral measures.

引用

页码：9031 / 9036

页数：6

共 48 条

[11] Distribution of bone morphogenetic protein and bone morphogenetic protein receptor transcripts in the rodent nervous system and up-regulation of bone morphogenetic protein receptor type II in hippocampal dentate gyrus in a rat model of global cerebral ischemia [J].