Stimulation of neurotrophic factors and inhibition of proinflammatory cytokines by exogenous application of triiodothyronine in the rat model of ischemic stroke

被引：33

作者：

Sabbaghziarani, Fatemeh ^{[1
]}

Mortezaee, Keywan ^{[2
]}

Akbari, Mohammad ^{[3
]}

Kashani, Iraj Ragerdi ^{[3
]}

Soleimani, Mansooreh ^{[4
,5
]}

Hassanzadeh, Gholamreza ^{[3
]}

Zendedel, Adib ^{[6
,7
]}

机构：

[1] Qazvin Univ Med Sci, Sch Med, Dept Anat, Qazvin, Iran

[2] Kurdistan Univ Med Sci, Sch Med, Dept Anat, Sanandaj, Iran

[3] Univ Tehran Med Sci, Sch Med, Dept Anat, Poursina St, Tehran, Iran

[4] Iran Univ Med Sci, Cellular & Mol Res Ctr, Tehran, Iran

[5] Iran Univ Med Sci, Sch Med, Dept Anat, Tehran, Iran

[6] Rhein Westfal TH Aachen, Inst Neuroanat, Aachen, Germany

[7] Giulan Univ Med Sci, Fac Med, Dept Anat Sci, Rasht, Iran

来源：

CELL BIOCHEMISTRY AND FUNCTION | 2017年 / 35卷 / 01期

关键词：

inflammation; ischemia; neurogenesis; subventricular zone; triiodothyronine; HORMONE; BRAIN; INFLAMMATION;

D O I：

10.1002/cbf.3244

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is a positive relation between decreases of triiodothyronine (T3) amounts and severity of stroke. The aim of this study was to evaluate the effect of exogenous T3 application on levels of neurogenesis markers in the subventricular zone. Cerebral ischemia was induced by middle cerebral artery occlusion in male Wistar rats. There were 4 experimental groups: sham, ischemic, vehicle, and treatment. Rats were injected with T3 (25 mu g/kg, IV injection) at 24 hours after ischemia. Animals were sacrificed at day 7 after ischemia. There were high levels of brain-derived neurotrophic factor, nestin, and Sox2 expressions in gene and protein levels in the T3 treatment group (P <= .05 vs ischemic group). Treatment group showed high levels of sera T3 and thyroxine (T4) but low levels of thyrotropin (TSH), tumor necrosis factor-a, and interleukin-6 (P <= .05 vs ischemic group) at day 4 after ischemia induction. Findings of this study revealed the effectiveness of exogenous T3 application in the improvement of neurogenesis possibly via regulation of proinflammatory cytokines.

引用

页码：50 / 55

页数：6

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