Ischemic, traumatic and neurodegenerative brain inflammatory changes

被引：7

作者：

Dugue, Rachelle ^{[1
,2
]}

Barone, Frank C. ^{[1
,2
]}

机构：

[1] Suny Downstate Med Ctr, Dept Neurol, Brooklyn, NY 11203 USA

[2] Suny Downstate Med Ctr, Dept Physiol & Pharmacol, Brooklyn, NY 11203 USA

来源：

FUTURE NEUROLOGY | 2016年 / 11卷 / 01期

关键词：

brain injury; complement; inflammasome; innate immunity; neurodegeneration; neurodegenerative disease; neuroimmunology; neuroinflammation; stroke; traumatic brain injury;

D O I：

10.2217/fnl.16.5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This review serves to link the role of the immune system in the neuropathology of acute ischemic stroke, traumatic brain injury and neurodegenerative disease. The blood-brain barrier delineates the CNS from the peripheral immune system. However, the blood-cerebrospinal fluid barrier acts as a gate between the periphery and the brain, permitting immune activity crosstalk and modulation. In acute ischemic stroke, traumatic brain injury and other neurodegenerative diseases, the blood-brain barrier is compromised and an influx of inflammatory cells and plasma proteins occurs, resulting in edema, demyelination, cell dysfunction and death, and neurobehavioral changes. The role of the complement system, key cytokines, microglia and other neuroglia in brain degenerative pathology will be discussed.

引用

页码：77 / 96

页数：20

共 146 条

[1] Inflammasome proteins in cerebrospinal fluid of brain-injured patients as biomarkers of functional outcome Clinical article [J].

Adamczak, Stephanie ;

Dale, Gordon ;

Vaccari, Juan Pablo de Rivero ;

Bullock, M. Ross ;

Dietrich, W. Dalton ;

Keane, Robert W. .

JOURNAL OF NEUROSURGERY, 2012, 117 (06) :1119-1125

[2] Pre-Existing Hypertension Dominates γδT Cell Reduction in Human Ischemic Stroke [J].

Adamski, Mateusz G. ;

Li, Yan ;

Wagner, Erin ;

Yu, Hua ;

Seales-Bailey, Chloe ;

Durkin, Helen ;

Hao, Qing ;

Soper, Steven A. ;

Murphy, Michael ;

Baird, Alison E. .

PLOS ONE, 2014, 9 (05)

[3] Complement Component C3 and Butyrylcholinesterase Activity Are Associated with Neurodegeneration and Clinical Disability in Multiple Sclerosis [J].

Aeinehband, Shahin ;

Lindblom, Rickard P. F. ;

Al Nimer, Faiez ;

Vijayaraghavan, Swetha ;

Sandholm, Kerstin ;

Khademi, Mohsen ;

Olsson, Tomas ;

Nilsson, Bo ;

Ekdahl, Kristina Nilsson ;

Darreh-Shori, Taher ;

Piehl, Fredrik .

PLOS ONE, 2015, 10 (04)

[4] Ischemic stroke and traumatic brain injury: The role of the kallikrein-kinin system [J].

Albert-Weissenberger, Christiane ;

Siren, Anna-Leena ;

Kleinschnitz, Christoph .

PROGRESS IN NEUROBIOLOGY, 2013, 101 :65-82

[5] The complement cascade: Yin-Yang in neuroinflammation - neuro-protection and -degeneration [J].

Alexander, Jessy John ;

Anderson, Aileen Judith ;

Barnum, Scott Robert ;

Stevens, Beth ;

Tenner, Andrea Joan .

JOURNAL OF NEUROCHEMISTRY, 2008, 107 (05) :1169-1187

[6] Astrocyte-neuron metabolic relationships: for better and for worse [J].

Allaman, Igor ;

Belanger, Mireille ;

Magistretti, Pierre J. .

TRENDS IN NEUROSCIENCES, 2011, 34 (02) :76-87

[7] Interleukin-1 and neuronal injury [J].

Allan, SM ;

Tyrrell, PJ ;

Rothwell, NJ .

NATURE REVIEWS IMMUNOLOGY, 2005, 5 (08) :629-640

[8] Inflammation in neurodegenerative diseases-an update [J].

Amor, Sandra ;

Peferoen, Laura A. N. ;

Vogel, Daphne Y. S. ;

Breur, Marjolein ;

van der Valk, Paul ;

Baker, David ;

van Noort, Johannes M. .

IMMUNOLOGY, 2014, 142 (02) :151-166

[9] Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death [J].

Arumugam, Thiruma V. ;

Tang, Sung-Chun ;

Lathia, Justin D. ;

Cheng, Aiwu ;

Mughal, Mohamed R. ;

Chigurupati, Srinivasulu ;

Magnus, Tim ;

Chan, Sic L. ;

Jo, Dong-Gyu ;

Ouyang, Xin ;

Fairlie, David P. ;

Granger, Daniel N. ;

Vortmeyer, Alexander ;

Basta, Milan ;

Mattson, Mark P. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (35) :14104-14109

[10] Complement mediators in ischemia-reperfusion injury [J].

Arumugam, Thiruma V. ;

Magnus, Tim ;

Woodruff, Trent M. ;

Proctor, Lavinia M. ;

Shiels, Ian A. ;

Taylor, Stephen M. .

CLINICA CHIMICA ACTA, 2006, 374 (1-2) :33-45

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