Opinion - Spinal cord repair strategies: why do they work?

被引：286

作者：

Bradbury, Elizabeth J.

McMahon, Stephen B.

机构：

[1] Kings Coll London, Neurorestorat Grp, London SE1 1UL, England

[2] Kings Coll London, London Pain Consortium, London SE1 1UL, England

来源：

NATURE REVIEWS NEUROSCIENCE | 2006年 / 7卷 / 08期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1038/nrn1964

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

There are now numerous preclinical reports of various experimental treatments promoting some functional recovery after spinal cord injury. Surprisingly, perhaps, the mechanisms that underlie recovery have rarely been definitively established. Here, we critically evaluate the evidence that regeneration of damaged pathways or compensatory collateral sprouting can promote recovery. We also discuss several more speculative mechanisms that might putatively explain or confound some of the reported outcomes of experimental interventions.

引用

页码：644 / 653

页数：10

共 133 条

[11] RECOVERY FROM SPINAL-CORD INJURY MEDIATED BY ANTIBODIES TO NEURITE GROWTH-INHIBITORS [J].