Protein turnover on the scale of the proteome

被引：57

作者：

Doherty, Mary K. ^{[1
]}

Beynon, Robert J. ^{[1
]}

机构：

[1] Univ Liverpool, Fac Vet Sci, Prot Funct Grp, Liverpool L69 7ZJ, Merseyside, England

来源：

EXPERT REVIEW OF PROTEOMICS | 2006年 / 3卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

continuous infusion; flooding dose; mass isotopomer distribution analysis (MIDA); mass spectrometry; protein turnover; proteomics; radioisotopes; stable isotopes;

D O I：

10.1586/14789450.3.1.97

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein turnover is a neglected dimension in postgenomic studies, defining the dynamics of changes in protein expression and forging a link between transcriptome, proteome and metabolome. Recent advances in postgenomic technologies have led to the development of new proteomic techniques to measure protein turnover on a proteome-wide scale. These methods are driven by stable isotope metabolic labeling of cells in culture or in intact animals. This review considers the merits and difficulties of different methods that allow access to proteome dynamics.

引用

页码：97 / 110

页数：14

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